2. Signaling Pathways
  3. GPCR/G Protein
  4. G Protein-coupled Receptor Kinase (GRK)
  5. GRK2 Isoform
  6. GRK2 Degrader

GRK2 Degrader

GRK2 Degrader (1):

Cat. No. Product Name Effect Purity
  • HY-177948
    GRK2 degrader-1
    		Degrader 98.83%
    GRK2 degrader-1 (compound 1) is a potent and orally active GRK2 degrader. GRK2 degrader-1 degrades GRK2 via the ubiquitin-proteasome pathway. GRK2 degrader-1 inhibits right ventricular remodeling and elevation of pulmonary artery pressure in a pulmonary artery hypertension (PAH) mouse model. GRK2 degrader-1 can be used for PAH research.