2. Signaling Pathways
  3. GPCR/G Protein
  4. GPR88
  5. GPR88 Agonist

GPR88 Agonist

GPR88 Agonists (5):

Cat. No. Product Name Effect Purity
  • HY-167856A
    RTI-122 dihydrochloride
    		Agonist 99.36%
    RTI-122 dihydrochloride is a selective, blood-brain barrier-permeable GPR88 agonist (cAMP EC50=11 nM), with EC50 values of 11.5 nM and 155 nM for human and mouse GPR88, respectively ([35S]GTPγS assay). By activating the GPR88 receptor to regulate the cAMP signaling pathway and G protein activity, RTI-122 dihydrochloride significantly attenuates Binge-like drinking, reduces alcohol intake, and decreases alcohol-seeking motivation. RTI-122 dihydrochloride blocks the reinstatement of alcohol-seeking behavior without affecting water or sucrose intake. RTI-122 dihydrochloride exhibits metabolic stability in mice (T1/2=5.8 h) and can be used to investigate alcohol use disorder.
  • HY-156772
    GPR88 agonist 2
    		Agonist 99.57%
    GPR88 agonist 2 (compound 53) is a potent and brain-penetrantGPR88 agonist with an EC50 value of 14 µM in GPR88 cAMP functional assay.
  • HY-167856
    RTI-122
    		Agonist
    RTI-122 is a selective, blood-brain barrier-permeable GPR88 agonist (cAMP EC50=11 nM), with EC50 values of 11.5 nM and 155 nM for human and mouse GPR88, respectively ([35S]GTPγS assay). By activating the GPR88 receptor to regulate the cAMP signaling pathway and G protein activity, RTI-122 significantly attenuates Binge-like drinking, reduces alcohol intake, and decreases alcohol-seeking motivation. RTI-122 blocks the reinstatement of alcohol-seeking behavior without affecting water or sucrose intake. RTI-122 exhibits metabolic stability in mice (T1/2=5.8 h) and can be used to investigate alcohol use disorder.
  • HY-162660
    BI-9508
    		Agonist
    BI-9508 is a selective and cross the blood-brain barrier GPR88 agonist. BI-9508 has the potential for the research of neurological disorders.
  • HY-163096
    GPR88 agonist 3
    		Agonist
    GPR88 agonist 3 (compound 20) is a GPR88 agonist 3, with an EC50 of 204 nM. GPR88 agonist 3 can be used for psychiatric and neurodegenerative disorders research.