Isotope-Labeled Compounds

Isotope-labeled compounds are chemical substances in which some atoms in their molecules are replaced by isotope atoms. The range of stable isotope products can cover from gases to complex molecules. Isotope-labeled compounds could provide a site-specific investigation of structures, making molecules easily detectable by mass spectrometry and NMR, and maintaining the physico-chemical properties of the target molecule at the same time. MCE isotope-labeled compounds are all stable isotope-labeled compounds and are non-radioactive labeled substances. MCE isotope-labeled compounds are unique tools for identifying and understanding biological and chemical processes. Stable isotope-labeled products are now getting more and more popular among scientists. The scope of application is gradually penetrating into various scientific fields, such as life sciences, food and medicine, agriculture, environment, geology, etc. Stable isotope-labeled compounds have a wide range of applications in the Life Science areas, such as Metabolomics, Proteomics, Clinical studies, Deuterium drugs, etc.

Isotope-Labeled Compounds Inhibitors (4)

Isotope-Labeled Compounds Related Products (10876):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-W026772S1

Fluorene-d₈
Fluorene-d₈ is the deuterium labeled Fluorene (HY-W026772). Fluorene is an orally active polycyclic aromatic hydrocarbon (PAH) and a precursor to other fluorene-based compounds. Fluorene and its derivatives serve as dye precursors for fluorene synthesis. In A549 cells, Fluorene induces oxidative stress and inflammatory responses by increasing ROS and SOD generation, exacerbating lipid peroxidation, modulating antioxidant enzyme activity, and upregulating the expression of pro-inflammatory factors TNF-α and IL-6. In vivo, Fluorene exhibits anxiolytic activity. Fluorene holds potential for research in inflammation and neurological disorders.

HY-141856S

Acrolein 2,4-dinitrophenylhydrazone-3,5,6-d₃		99.95%
Acrolein 2,4-dinitrophenylhydrazone-3,5,6-d₃ is the deuterium labeled Acrolein 2,4-dinitrophenylhydrazone-3,5,6.

HY-134423S

Stearoyl coenzyme A-¹³C₁₈ lithium
Stearoyl coenzyme A-¹³C₁₈ (lithium) is the ¹³C labeled Stearoyl coenzyme A lithium. Stearoyl coenzyme A (Stearoyl-CoA) lithium is an active compound that can be used as a substrate for the determination of stearoyl-Coenzyme desaturase in microsomes.

HY-50895S2

Gefitinib-d₃		98.39%
Gefitinib-d₃ (ZD1839-d₃) is the deuterium labeled Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC₅₀ of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC₅₀ of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity.

HY-13577S

Oclacitinib-¹³C-d₃		99.15%
Oclacitinib-¹³C-d₃ is the deuterium and ¹³C labeled Oclacitinib.

HY-W442217

4-Fluorobenzaldehyde-2,3,5,6-d₄		99.73%
4-Fluorobenzaldehyde-2,3,5,6-d₄ is the deuterium labeled 4-Fluorobenzaldehyde-2,3,5,6-d₄.

HY-Y0674S

Dicyandiamide-¹³C₂,¹⁵N₂		99.90%
Dicyandiamide-¹³C₂,¹⁵N₂ is the ¹⁵N₂ labeled Dicyandiamide.

HY-B0166S8

L-Ascorbic acid-¹³C₆-1		99.37%
L-Ascorbic acid-¹³C₆-1 (L-Ascorbate-1; Vitamin C-¹³C₆-1) is a ¹³C labeled L-Ascorbic acid (HY-B0166). L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Ca_v3.2 channels with an IC₅₀ of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor. L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells.

HY-41417S1

Octanoic acid-d₃		99.1%
Octanoic acid-d₃ is the deuterium labeled Octanoic acid. Octanoic acid (Caprylic acid) is an oily liquid with a slightly unpleasant rancid taste and used commercially in the production of esters used in perfumery and also in the manufacture of dyes.

HY-N7148S1

γ-Tocopherol-d₄		98.90%
γ-Tocopherol-d₄ is the deuterium labeled γ-Tocopherol. γ-Tocopherol (D-γ-Tocopherol) is a potent cyclooxygenase (COX) inhibitor. γ-Tocopherol is a naturally occurring form of Vitamin E in many plant seeds, such as corn oil and soybeans. γ-Tocopherol possesses antiinflammatory properties and anti-cancer activity.

HY-113294S

3-Hydroxykynurenine-¹³C₃,¹⁵N		99.0%
3-Hydroxykynurenine-¹³C₃,¹⁵N (3-Hydroxy-DL-kynurenine-¹³C₃,¹⁵N) is the ¹³C and ¹⁵N labeled 3-Hydroxykynurenine (HY-113294). 3-Hydroxykynurenine, a metabolite of tryptophan, is a potential endogenous neurotoxin whose increased levels have been described in several neurodegenerative disorders. 3-Hydroxykynurenine induces neuronal apoptosis.

HY-100634S

4-Hydroxypropranolol-d₇ hydrochloride		98.68%
4-Hydroxypropranolol-d₇ (hydrochloride) is a deuterium labeled 4-Hydroxypropranolol hydrochloride. 4-Hydroxypropranolol hydrochlorid is an active metabolite of Propranolol, with potency comparable to Propranolol. 4-Hydroxypropranolol hydrochlorid inhibits β1- and β2-adrenergic receptors with pA2 values of 8.24 and 8.26, respectively. 4-Hydroxypropranolol hydrochlorid has intrinsic sympathomimetic activity, membrane stabilizing activity and potent antioxidant properties.

HY-13626S

Spisulosine-d₃		99.0%
Spisulosine-d₃ (ES-285-d₃) is deuterium labeled Spisulosine (HY-13626). Spisulosine is an antiproliferative (antitumoral) compound of marine origin. Spisulosine inhibits the growth of the prostate PC-3 and LNCaP cells through intracellular ceramide accumulation and PKCζ activation. Spisulosine induces apoptosis in PC-3 and LNCaP cells.

HY-146906S

C18 Glucosyl(ß) ceramide-d₅		99%
C18 Glucosyl(ß) ceramide-d₅ is deuterium labeled C18 Glucosyl(ß) ceramide.

HY-159192S

SADDNIKTPAE(Arg-¹³C₆,¹⁵N₄)LLGPLPPSADDNLKT TFA
SADDNIKTPAE(Arg-¹³C6,¹⁵N4)LLGPLPPSADDNLKT (TFA) is the ¹³C and ¹⁵N labeled isotope of SADDNIKTPAE-LLGPLPPSADDNLKT (TFA).

HY-15453S

Devimistat-d₁₀		99.79%
Devimistat-d10 is the deuterium-labeled Devimistat (HY-15453).

HY-123007S

13(S)-HODE-d₄		99.2%
13(S)-HODE-d₄ is the deuterium labeled 13(S)-HODE.

HY-17386S1

Rosiglitazone-d₄		99.72%
Rosiglitazone-d₄ is deuterated labeled Rosiglitazone (HY-17386). Rosiglitazone (BRL 49653) is an orally active selective PPARγ agonist (EC₅₀: 60 nM, K_d: 40 nM). Rosiglitazone is an TRPC5 activator (EC₅₀: 30 μM) and TRPM3 inhibitor. Rosiglitazone can be used in the research of obesity and diabetes, senescence, ovarian cancer.

HY-W249514

1-Methyl-1H-pyrazole-4-boronic acid pinacol ester-d₃		≥98.0%
1-Methyl-1H-pyrazole-4-boronic acid pinacol ester-d₃ is the deuterium labeled 1-Methyl-1H-pyrazole-4-boronic acid pinacol ester (HY-I0308). 1-Methyl-1H-pyrazole-4-boronic acid pinacol ester is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-144250S

Glycyl-L-proline-¹⁵N,d₂ trifluoroacetate		98.86%
Glycyl-L-proline-¹⁵N,d₂ (trifluoroacetate) is a ¹⁵N-labeled and deuterium labeled Glycyl-L-proline.

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