α-Linolenic acid-d5
α-Linolenic acid-d5 is the deuterium labeled α-Linolenic acid. α-Linolenic acid, isolated from seed oils, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer.
For research use only. We do not sell to patients.
- CAS No.: 145191-04-4
- Formula: C18H25D5O2
- Molecular Weight:283.46
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 145191-04-4
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Unlabeled Cas 463-40-1
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Appearance Liquid
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Molecular Weight 283.46
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Formula C18H25D5O2
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Color Colorless to light yellow
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SMILES
[2H]C([2H])(C([2H])(/C=C\C/C=C\C/C=C\CCCCCCCC(O)=O)[2H])[2H]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : 100 mg/mL (352.78 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (267 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Yang Q, et al. Anti-thrombotic effects of α-linolenic acid isolated from Zanthoxylum bungeanum Maxim seeds. BMC Complement Altern Med. 2014 Sep 23;14:348. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5278 mL | 17.6392 mL | 35.2783 mL | 88.1959 mL |
| 5 mM | 0.7056 mL | 3.5278 mL | 7.0557 mL | 17.6392 mL | |
| 10 mM | 0.3528 mL | 1.7639 mL | 3.5278 mL | 8.8196 mL | |
| 15 mM | 0.2352 mL | 1.1759 mL | 2.3519 mL | 5.8797 mL | |
| 20 mM | 0.1764 mL | 0.8820 mL | 1.7639 mL | 4.4098 mL | |
| 25 mM | 0.1411 mL | 0.7056 mL | 1.4111 mL | 3.5278 mL | |
| 30 mM | 0.1176 mL | 0.5880 mL | 1.1759 mL | 2.9399 mL | |
| 40 mM | 0.0882 mL | 0.4410 mL | 0.8820 mL | 2.2049 mL | |
| 50 mM | 0.0706 mL | 0.3528 mL | 0.7056 mL | 1.7639 mL | |
| 60 mM | 0.0588 mL | 0.2940 mL | 0.5880 mL | 1.4699 mL | |
| 80 mM | 0.0441 mL | 0.2205 mL | 0.4410 mL | 1.1024 mL | |
| 100 mM | 0.0353 mL | 0.1764 mL | 0.3528 mL | 0.8820 mL |
α-Linolenic acid-d5 Related Classifications
HY-N0728S Related Classifications
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