CNT3
CNT3 (SLC28A3) is a concentrative nucleoside transporter that supports nucleoside salvage and therapeutic nucleoside-derivative uptake across plasma membranes[1]. Mechanistically, hCNT3 shows broad substrate selectivity and uniquely transports nucleosides through both sodium- and proton-coupled mechanisms, unlike hCNT1 and hCNT2[2]. Structural studies show that human CNT3 forms a trimeric architecture, and oligomerization supports transporter stability, function, and nucleoside translocation[1][3]. In airway epithelial models, CNT3 contributes to apical adenosine elimination, thereby regulating adenosine-mediated inflammatory signaling[4]. In HIV-1-infected adipose tissue, SLC28A3 mRNA is upregulated, linking CNT3 expression to antiretroviral and lipodystrophy-related research contexts[5]. Compared with related isoforms, hCNT1 preferentially transports pyrimidine nucleosides, hCNT2 preferentially transports purine nucleosides, whereas hCNT3 has the broadest selectivity and widest expression profile[2][3]. For experimental applications, CNT3 remains relevant to nucleoside analogue pharmacology because hCNT proteins mediate uptake of many antiviral and anticancer nucleoside-derived drugs[2].
References:
- [1]. Zhou Y, et al. Cryo-EM structure of the human concentrative nucleoside transporter CNT3. PLoS Biol. 2020 Aug 10;18(8):e3000790. [Content Brief]
- [2]. Pastor-Anglada M, et al. SLC28 genes and concentrative nucleoside transporter (CNT) proteins. Xenobiotica. 2008 Jul;38(7-8):972-94. [Content Brief]
- [3]. Stecula A, et al. Human Concentrative Nucleoside Transporter 3 (hCNT3, SLC28A3) Forms a Cyclic Homotrimer. Biochemistry. 2017 Jul 11;56(27):3475-3483. [Content Brief]
- [4]. Hirsh AJ, et al. Adenosine deaminase 1 and concentrative nucleoside transporters 2 and 3 regulate adenosine on the apical surface of human airway epithelia: implications for inflammatory lung diseases. Biochemistry. 2007 Sep 11;46(36):10373-83. [Content Brief]
- [5]. Guallar JP, et al. Altered expression of nucleoside transporter genes (SLC28 and SLC29) in adipose tissue from HIV-1-infected patients. Antivir Ther. 2007;12(6):853-864.
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CNT3 Related Products (2)
Related Products (2)
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dMeThPmR
0 ImagesCat. No.: HY-177747CAS No.: 1262032-37-0dMeThPmR, a ribonucleoside derivative, is a potent and selective human nucleoside transporter 1 (hCNT1) inhibitor (Ki = 0.3-0.98 μM). dMeThPmR exhibit weak inhibitory activity on hCNT2 (IC50 = 133 μM) and hCNT3 (Ki = 32.7 μM). dMeThPmR can protect cells from the toxicity of nucleoside drugs. dMeThPmR can be used for the research of cancer.
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MeThPmR
0 ImagesCat. No.: HY-177746CAS No.: 1262032-38-1MeThPmR, a ribonucleoside derivative, is a potent and selective human nucleoside transporter 1 (hCNT1) inhibitor (Ki/sub> = 0.16-0.69 μM). MeThPmR exhibit weak inhibitory activity on hCNT2 (IC50 = 360 μM) and hCNT3 (Ki = 4.7 μM). MeThPmR can protect cells from the toxicity of nucleoside drugs. MeThPmR can be used for the research of cancer.
