Phytohormone Inhibitor

TSPC is a phytohormone gibberellin (GA) perception inhibitor with an IC₅₀ value of 10 μM in vitro.

7-Methyl-1-naphthyl acetic acid is a potent inhibitor of auxin action in plants. 7-Methyl-1-naphthyl acetic acid inhibits AUX1, PIN, and ABCB protein-mediated auxin transport expressed in yeast. 7-Methyl-1-naphthyl acetic acid can be used in auxin dependent development .

KeIKK5 is a strigolactone (SL) biosynthesis inhibitor. KeIKK5 significantly reduces the level of 4-deoxystrigolactone (4-DO) in rice by inhibiting the activity of CYP711A enzyme. KeIKK5 can effectively inhibit the germination of root parasitic weeds. KeIKK5 can be used in the research of plant hormone regulation and new agricultural herbicides.

Fujenal is a kaurene-type diterpenoid found in Gibberella fujikuroi. Fujenal shows moderate inhibition against HeLa tumor cells and acts as a gibberellin biosynthesis inhibitor. Fujenal is promising for research of plant growth regulators and antitumor agents.

Brassinazole (0.5, 1, 5 μM) causes markedly deformed seedlings, whose morphology is similar to that of BR-deficient mutants. Brassinazole causes cress dwarfism, altering leaf morphology such as the typical downward curl and dark green appearance of Arabidopsis BR-deficient mutants. However, administration of 10 nM BR reversed dwarfism.

Herbicidal agent 8 (Compound 9w) targets the auxin indole-3-acetic acid (IAA, IC₅₀=4.389 μM), disrupting the physiological activities of plant cells and eventually causing plant death. Herbicidal agent 8 exhibits herbicidal activity against broadleaf weeds and grass weeds.

GA3ox-IN-1 (Compound 10e) is a GA3β-hydroxylase (GA3ox) inhibitor. GA3ox-IN-1 inhibits Arabidopsis root growth with an IC₅₀ of 90 μM. GA3ox-IN-1 also suppresses the elongation of rice second leaf sheath. GA3ox-IN-1 can alleviate oxidative damage to Arabidopsis seedlings under NaCl salt stress and reduce the accumulation of superoxide anion.

3,4,5-Triiodobenzoic acid is an auxin transport inhibitor. 3,4,5-Triiodobenzoic acid stimulates specific [³H]verapamil binding to zucchini microsomes. 3,4,5-Triiodobenzoic acid also increases specific [³H]verapamil binding to rabbit skeletal muscle membranes. 3,4,5-Triiodobenzoic acid can be used in the research of smooth muscle contraction.

DHGA5 (exo-16,17-Dihydro-gibberellin A5-13-acetate) is a GA3β-hydroxylase (OsGA3ox2) inhibitor. DHGA5 inhibits Arabidopsis root growth with an IC₅₀ of 97 μM. DHGA5 also suppresses the elongation of rice second leaf sheath. DHGA5 can alleviate oxidative damage to Arabidopsis seedlings under NaCl salt stress and reduce the accumulation of superoxide anion.