Succinate Dehydrogenase Inhibitor

Succinate dehydrogenase-IN-9 (Compound Iik) is a succinate dehydrogenase inhibitor (IC₅₀: 3.6 μM). Succinate dehydrogenase-IN-9 exhibits potent inhibitory activity against various fungal species (eg: inhibits S. sclerotiorum with an EC₅₀ value of 1.14 μg/mL. Succinate dehydrogenase-IN-9 enhances the nitrate reductase activity, thereby facilitating plant growth.

Succinate dehydrogenase-IN-8 (compound i19) is a potent succinate dehydrogenase (SDH) inhibitor. Succinate dehydrogenase-IN-8, an indene amino acid derivative, demonstrates potent in vitro antifungal activity against Rhizoctonia solani (EC₅₀=0.1843 mg/L), Botrytis cinerea (EC₅₀=0.4829 mg/L), and Sclerotinia sclerotiorum (EC₅₀=0.1349 mg/L).

Tambulin is an orally active flavonol compound found in Zanthoxylum armatum. Tambulin can inhibit cell proliferation, induce apoptosis and inhibit ROS production. Tambulin upregulates cleaved caspase-3, cleaved caspase-9, and Bax, downregulates Bcl-2 levels. Tambulin can stimulate glucose-dependent insulin secretion and induce endothelium-independent vasorelaxation. Tambulin binds to succinate dehydrogenase (SDH) (Ki = 11.02 μM) and shows significant ferric reducing power. Tambulin can enhances oxidative stress resistance, reduces, lipofuscin deposits, lipid levels, α-synuclein levels, improves locomotary behavior, and dopamine levels in in age-synchronized L1 hermaphrodite Caenorhabditis elegans models of ageing and Parkinson's disease. Tambulin can be used for the researches of Parkinson's disease, lung squamous cell carcinoma, and diabetes.

SDH-IN-18 (Compound 3a) is an inhibitor for succinate dehydrogenase (SDH) with an IC₅₀ of 8.70 mg/L. SDH-IN-18 destroys fungal morphology and reproduction, exhibits antifungal activity against Rhizoctonia solani and Sclerotinia sclerotiorum with EC₅₀ of 0.48 and 1.4 mg/L.

SDH-IN-22 (Compound SEZC7) is the inhibitor for succinate dehydrogenase (SDH) with an IC₅₀ of 16.6 μM. SDH-IN-22 exhibits antifungal activity that inhibits Magnaporthe grisea with an EC₅₀ of 0.5 mg/L.

Flubeneteram is a succinate dehydrogenase inhibitor with an IC₅₀ of 0.0484 μM. Flubeneteram disrupts succinate dehydrogenase activity. Flubeneteram demonstrates protective effects against Rhizoctonia solani and Sphaerotheca fuliginea in preclinical models. Flubeneteram can be used for research related to fungal infections.

SDH-IN-15 (Compound 5e) is an inhibitor of succinate dehydrogenase (SDH) (IC₅₀=2.04 μM). SDH-IN-15 has significant antifungal activity. SDH-IN-15 blocks the mitochondrial respiratory chain of the fungus through inhibition of SDH, resulting in fungal death.

Succinate dehydrogenase-IN-6 (Compound E23) is the inhibitor for succinate dehydrogenase that inhibits SDH in Rhizoctonia solani with an IC₅₀ of 11.76 μM. Succinate dehydrogenase-IN-6 disrupts fungal cell membrane, exhibits board-spectrum antifungal activity that inhibits R. solani, V. dahliae, A. solani and C. gloeosporioides with EC₅₀s of 0.41, 0.27, 1.15, 0.27 μg/mL, respectively. Succinate dehydrogenase-IN-6 exhibits no significant toxicity in rice and zebrafish (LC₅₀ > 12.5 μg/mL).

Succinate dehydrogenase-IN-3 (Ig) is an inhibitor of Succinate dehydrogenase (SDH). Succinate dehydrogenase-IN-3 has antifungal activity.

Dimethylmalonic acid (Standard) (Dimethylpropanedioic acid (Standard)) is the analytical standard of Dimethylmalonic acid (HY-W007894). This product is intended for research and analytical applications. Dimethylmalonic acid (Dimethylpropanedioic acid) is a succinate dehydrogenase inhibitor. Dimethylmalonic acid competitively inhibits succinate dehydrogenase, reduces SDH-mediated succinate accumulation, blocks a key step in oxidative phosphorylation, and decreases anti-inflammatory cytokine secretion and ROS production. Dimethylmalonic acid can be used in research on autism spectrum disorders.

SDH-IN-48 is a succinate dehydrogenase (SDH) inhibitor, with an IC₅₀ of 0.056 μM against porcine SDH. SDH-IN-48 binds to the SDH active pocket through multiple non-covalent interactions. SDH-IN-48 can be used in related research on rice sheath blight disease.

Succinate dehydrogenase-IN-4 (Compound 4b) is the inhibitor for succinate dehydrogenase with an IC₅₀ of 3.38 μM. Succinate dehydrogenase-IN-4 exhibits antifungal activity against Physalospora piricola and Colletotrichum orbiculare with EC₅₀ of 16.33 μM and 18.06 μM.

SDH-IN-25 is a succinate dehydrogenase (SDH) inhibitor (IC₅₀ = 4.82 mg/L). SDH-IN-25 exhibited broad-spectrum and potent antifungal activity. SDH-IN-25 mimics the interaction pattern of commercial fungicide Fluxapyroxad (HY-135549) through binding to SDH amino acid residues (TRP173, TYR58, and ARG43). SDH-IN-25 can induce hyphal morphology, interfere with respiratory metabolism by binding to complex II, generate reactive oxygen species (ROS), and affect mitochondrial membrane potential (MMP) in mycelia. SDH-IN-25 can be studied in research for agricultural disease control.

SDH-IN-14 (Compound Z2) is an inhibitor of succinate dehydrogenase (SDH). SDH-IN-14 has antifungal activity (EC₅₀=2.7 μg/mL) against B.cinerea. SDH-IN-14 acts by disrupting the integrity of the cell wall and cell membrane.

Enpyracymid is a succinate dehydrogenase inhibitor (SDHI) fungicide with fungicidal activity against fungal. It can be used in studies related to Fusarium head blight (FHB).

SDH-IN-17 (compound C32), a hydrazide-containing flavonol derivative, is a potent succinate dehydrogenase (SDH) inhibitor with an IC₅₀ of 8.42 μM. SDH-IN-17 can occupy the active site and form strong interactions with the key residues of SDH. SDH-IN-17 exhibits antifungal activity against Rhizoctonia solani (EC₅₀=0.170 μg/mL). SDH-IN-17 disrupts the normal growth of hyphae by affecting the structural integrity of the cell membrane and cellular respiration. SDH-IN-17 has the potential for plant disease control research.

Flutolanil (Standard) is the analytical standard of Flutolanil (HY-B2011). This product is intended for research and analytical applications. Flutolanil is a succinate dehydrogenase complex inhibitor and fungicide. Flutolanil blocks electron transfer between the redox center of succinate dehydrogenase and coenzyme Q, inhibits mycelial oxygen consumption, and suppresses mycelial growth. Flutolanil induces acute and sublethal toxicity in zebrafish at different life stages. Flutolanil can be used in studies on plant disease control.

SDH-IN-44 is a succinate dehydrogenase (SDH) inhibitor with an IC₅₀ of 12.5 μg/mL against Alternaria solani. SDH-IN-44 exhibits antifungal activity and inhibits fungal mycelial growth. SDH-IN-44 is applicable to research related to fungal infections.

Antimicrobial agent-51 is an antifungal agent that increases ROS levels, reduces mitochondrial membrane potential, alters hyphal morphology, and impairs cell membrane integrity. Antimicrobial agent-51 inhibits succinate dehydrogenase (SDH) with an IC₅₀ of 0.76 μg/mL against Colletotrichum gloeosporioides. Antimicrobial agent-51 exhibits control efficacy against Alternaria solani on tomato fruits and shows low toxicity to plant and mammalian cells. Antimicrobial agent-51 can be used for the research of plant fungal diseases.

SDH-IN-28 is a succinate dehydrogenase inhibitor with an IC₅₀ value of 2.65 mg/L. SDH-IN-28 demonstrates broad-spectrum fungicidal efficacy, with EC₅₀ values of 0.21 (Valsa mali), 0.95 (Botrytis cinerea), 0.64 (Rhizoctonia solani), 1.33 (Fusarium graminearum), and 0.66 mg/L (Gaeumannomyces graminis). SDH-IN-28 effectively prevents V. mali infection in apples.