-
SWI/SNF Complex Related Products (91)
Related Products (91)
-
PBRM1-BD2-IN-3
0 ImagesCat. No.: HY-151530CAS No.: 2819989-58-5PBRM1-BD2-IN-3 (compound 12) is a potent PBRM1-BD2 inhibitor with an IC50 value of 1.1 μM. PBRM1-BD2 Inhibitor can be used to research anticancer.
-
PROTAC SMARCA2/4 degrader-17
0 ImagesCat. No.: HY-163870CAS No.: 2568276-88-8
-
PROTAC SMARCA2/4 degrader-29
0 ImagesCat. No.: HY-162743CAS No.: 2568273-82-3
-
PBRM1-BD2-IN-6
0 ImagesCat. No.: HY-151533CAS No.: 2819989-67-6PBRM1-BD2-IN-6 is a potent PBRM1 bromodomain inhibitor with an IC50 value of 0.22 μM. PBRM1-BD2-IN-6 shows antiproliferation activity. PBRM1-BD2-IN-6 has the potential for the research of PBRM1-dependent cancer.
-
PBRM1-BD2-IN-1
0 ImagesCat. No.: HY-151528CAS No.: 1915012-21-3PBRM1-BD2-IN-1 is a selective and cell-active polybromo-1 (PBRM1) bromodomain inhibitor. PBRM1-BD2-IN-1 has binding affinity and inhibitory activity for PBRM1-BD2 with Kd and IC50 values of 0.7 μM and 0.2 μM, respectively. PBRM1-BD2-IN-1 can be used for the research of cancer.
-
BRM/BRG1 ATP-IN-5
0 ImagesCat. No.: HY-178481CAS No.: 2468046-57-1BRM/BRG1 ATP-IN-5 (Compound 6) is a BRG1/BRM inhibitor. BRM/BRG1 ATP-IN-5 acts on the BAF complex, which is involved in chromatin regulation and gene expression via ATP-dependent chromatin remodeling. BRM/BRG1 ATP-IN-5 demonstrates anti-tumor potential, particularly in cancers associated with BAF complex disorders.
-
DCSM06
0 ImagesCat. No.: HY-161888CAS No.: 924855-67-4DCSM06 is an inhibitor for the bromodomain of SWI/SNF chromatin remodeling complexe SMARCA2 with an IC50 of 9.7 μM
-
PROTAC SMARCA2/4 degrader-19
0 ImagesCat. No.: HY-163877CAS No.: 2568277-57-4
-
PROTAC SMARCA2 degrader-26
0 ImagesCat. No.: HY-169278CAS No.: 2760247-27-4PROTAC SMARCA2 degrader-26 (compound 45) is a potent SMARCA2 PROTAC degrader. PROTAC SMARCA2 degrader-26 induces SMARCA2 and SMARCA4 degradation in VCaP cells with the percent degradation of 94% and 57% for SMARCA2 and SMARCA4, respectively. PROTAC SMARCA2 degrader-26 shows antiproliferative activity.
-
SMARCA2-IN-2
0 ImagesCat. No.: HY-162740CAS No.: 2568055-24-1
-
PROTAC SMARCA2/4 degrader-31
0 ImagesCat. No.: HY-162744CAS No.: 2568273-83-4
-
PROTAC SMARCA2/4 degrader-35
0 ImagesCat. No.: HY-168225CAS No.: 2933253-85-9PROTAC SMARCA2/4-degrader-35 (Ex.43) is a SMARCA2/4 degrader with a DC50 <2.5 nM
-
DCB29
0 ImagesCat. No.: HY-111575CAS No.: 723245-31-6DCB29 is a selective inhibitor of the BPTF bromodomain, with an IC50 value of 13.2 μM. DCB29 can be used for the study of the BPTF-related diseases (such as bladder cancer, colorectal cancer, melanoma, leukemia, and other cancers).
-
JP-2-249
0 ImagesCat. No.: HY-161883CAS No.: 3036530-41-0
-
PROTAC SMARCA2 degrader-7
0 ImagesCat. No.: HY-159451CAS No.: 2568277-71-2PROTAC SMARCA2 degrader-7 (Compound I-428) is a PROTAC degrader for SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A (SMARCA) SMARCA2. PROTAC SMARCA2 degrader-7 degrades SMARCA2 and SMARCA4 in MV411 with DC50 of <100 and 100-500 nM. (Pink: Ligand for target protein (HY-159542); Black: Linker (HY-159538); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))
-
SMARCA2-IN-7
0 ImagesCat. No.: HY-161886CAS No.: 2270879-43-9SMARCA2-IN-7 (compound 12), a dual inhibitor of BRM and BRG1 (IC50 < 0.005 for both), has an anti-tumor proliferation effect that inhibits BRG1-deleted SKMEL5 tumor proliferation with a cell proliferation activity AAC50 of 13 nM in SKMEL5. The cell proliferation activity AAC50 of KRT880 in H1299 cells was 42 nM.
-
PROTAC SMARCA2 degrader-18
0 ImagesCat. No.: HY-169269CAS No.: 2408393-47-3PROTAC SMARCA2 degrader-18 (Example144) is a PROTAC SMARCA2 degrader. PROTAC SMARCA2 degrader-18 has the potential for the research of non-small cell lung cancer (NSCLC).
