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Cat. No.: HY-161888

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DCSM06

DCSM06 is an inhibitor for the bromodomain of SWI/SNF chromatin remodeling complexe SMARCA2 with an IC₅₀ of 9.7 μM

For research use only. We do not sell to patients.

CAS No.: 924855-67-4
Formula: C₂₁H₂₈N₂O
Molecular Weight:324.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

DCSM06 Chemical Structure

CAS No.: 924855-67-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

DCSM06 is an inhibitor for the bromodomain of SWI/SNF chromatin remodeling complexe SMARCA2 with an IC₅₀ of 9.7 μM^[1]

All SWI/SNF Complex Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HGC-27	IC₅₀	4.22 μM Compound: 46	Cytotoxicity against human HGC27 cells assessed as reduction in cell viability after 72 hrs by Alamar blue assay Cytotoxicity against human HGC27 cells assessed as reduction in cell viability after 72 hrs by Alamar blue assay	[PMID: 30128079]

Chemical Information

CAS No. 924855-67-4
Molecular Weight 324.46
Formula C₂₁H₂₈N₂O
SMILES

CC(C=C1)=CC=C1COC2=CC=C(CNCC3CCNCC3)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lu T, et al., Identification of small molecule inhibitors targeting the SMARCA2 bromodomain from a high-throughput screening assay. Acta Pharmacol Sin. 2018 Sep;39(9):1544-1552. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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