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SWI/SNF Complex Related Products (91)
Related Products (91)
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DC-BPi-03
0 ImagesDC-BPi-03 is a potent BPTF-BRD inhibitor with an IC50 of 698.3 nM and a Kd of 2.81 μM.
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SMD-3040 TFA
0 ImagesCat. No.: HY-156568APurity: 99.90%SMD-3040 TFA is a potent and selective SMARCA2 PROTAC degrader (DC50: 12 nM; Dmax: 91%). SMD-3040 TFA can inhibit tumor cell proliferation and exhibits antitumor activity. SMD-3040 TFA can be used in the study of tumors such as melanoma. (SMARCA2/4-ligand (HY-171765); HY-112078 VHL ligand (HY-112078))
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SMARCA2-IN-10
0 ImagesCat. No.: HY-W494890CAS No.: 82131-85-9SMARCA2-IN-10 (Compound 4) is a highly selective SMARCA2 ATPase domain inhibitor (IC50=17.676 μM). SMARCA2-IN-10 induces cell death in SMARCA4-deficient tumors. SMARCA2-IN-10 is promising for research of SMARCA4-mutant non-small cell lung cancer, small cell ovarian carcinoma, and melanoma.
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NVS-BPTF-1
0 ImagesNVS-BPTF-1, a chemical probe, is a selective inhibitor for bromodomain and PHD finger containing transcription factor (BPTF), with KD of 71 nM.
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BRM/BRG1 ATP Inhibitor-3
0 ImagesCat. No.: HY-148373CAS No.: 2368901-31-7BRM/BRG1 ATP Inhibitor-3 is a BRG1/BRM inhibitor. BRM/BRG1 ATP Inhibitor-3 inhibits BRM and BRG1 with IC50 values of 10.4 nM and 19.3 nM, respectively. BRM/BRG1 ATP Inhibitor-3 can be used for the research of cancers and BAF complex-related disorders.
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BRM/BRG1 ATP Inhibitor-4
0 ImagesCat. No.: HY-148374CAS No.: 2422030-94-0BRM/BRG1 ATP Inhibitor-4 is a BRG1/BRM inhibitor. BRM/BRG1 ATP Inhibitor-4 can be used for the research of cancers and BAF complex-related disorders.
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PROTAC SMARCA2/4 degrader-18
0 ImagesCat. No.: HY-163871CAS No.: 2568276-91-3
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BI-7190
0 ImagesCat. No.: HY-160286CAS No.: 2001082-11-5BI-7190 is a selective BPTF inhibitor (Kd = 3.5 nM). BI-7190 can be used in the research of cancer.
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DC-BPi-07
0 ImagesCat. No.: HY-178697CAS No.: 2758411-53-7DC-BPi-07 is a selective BPTF inhibitor with an IC50 value of 16.0 nM against BPTF-H4. DC-BPi-07 can be used in the research of leukemia.
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DC-BPi-11
0 ImagesCat. No.: HY-141703CAS No.: 2758411-61-7DC-BPi-11 is an inhibitor of bromodomain PHD finger transcription factor (BPTF), with an IC50 value of 698 nM. DC-BPi-11 shows remarkable inhibition against leukemia cell proliferation.
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SMARCA2-IN-8
0 ImagesCat. No.: HY-161887CAS No.: 2270875-93-7SMARCA2-IN-8 (Compound 13) is an orally active inhibitor for SWI/SNF chromatin remodeling complexe SMARCA2 (also known as Brahma homologue, BRM) and SMARCA4 (also known as Brahma-related gene 1, BRG1) with IC50 of 5 and 6 nM. SMARCA2-IN-8 inhibits the proliferation of SMARCA2 mutated cancer cell SKMEL5 with AAC50 of 5 nM. SMARCA2-IN-8 downregulates the SMARCA2-dependent KRT80 gene expression with AAC50 of 10 nM. SMARCA2-IN-8 exhibits antitumor efficacy and good pharmacokinetic characteristics in mice.
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IV-275
0 ImagesCat. No.: HY-155889IV-275 is an inhibitor of both BRG1 and BRM bromodomains. IV-275 increases the extent of DNA damage induced by Temozolomide (HY-17364) and Bleomycin (HY-108345). IV-275 inhibits the invasiveness of GBM cells. IV-275 enhances Temozolomide-induced cell death and the apoptosis-inducing activity of Temozolomide.
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PBRM1-BD2-IN-7
0 ImagesCat. No.: HY-151534CAS No.: 2819989-68-7PBRM1-BD2-IN-7 is a selective and cell-active polybromo-1 (PBRM1) bromodomain inhibitor. PBRM1-BD2-IN-7 has inhibitory activity for PBRM1-BD2 with an IC50 value of 0.29 μM. PBRM1-BD2-IN-7 can be used for the research of cancer.
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BRM/BRG1 ATP-IN-7
0 ImagesCat. No.: HY-178488CAS No.: 2468048-19-1BRM/BRG1 ATP-IN-7 (Compound Cpd69) is a selective dual BRM (SMARCA2) and BRG1 (SMARCA4) inhibitor with IC50 values of 12 nM and 8 nM, respectively. BRM/BRG1 ATP-IN-7 is promising for research of BRM/BRG1-dependent cancers (e.g., non-small cell lung cancer, Ewing sarcoma) and virus-associated diseases (e.g., HPV infection).
