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DC-BPi-11 

Cat. No.: HY-141703
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DC-BPi-11 is an inhibitor of bromodomain PHD finger transcription factor (BPTF), with an IC50 value of 698 nM. DC-BPi-11 shows remarkable inhibition against leukemia cell proliferation.

For research use only. We do not sell to patients.

DC-BPi-11 Chemical Structure

DC-BPi-11 Chemical Structure

CAS No. : 2758411-61-7

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Description

DC-BPi-11 is an inhibitor of bromodomain PHD finger transcription factor (BPTF), with an IC50 value of 698 nM. DC-BPi-11 shows remarkable inhibition against leukemia cell proliferation[1].

IC50 & Target

698 nM (BPTF)[1]

In Vitro

DC-BPi-11 (0.1 nM-1 μM; 24 h) inhibits BPTF in human leukemia MV-4-11 cells with an EC50 value of 120 nM[1].
DC-BPi-11 (0.01 μM-100 μM; 24 h) significantly inhibits the proliferation of human leukemia MV-4-11 cells (IC50=0.89 μM), and (2.5-20 μM; 24 h) decreases downstream oncogene expression[1].
DC-BPi-11 (0.6-50 μM; 24 h) dose-dependently decreases c-Myc protein level[1].
DC-BPi-11 is safety and shows minimal effects on normal cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: Human leukemia MV-4-11 cells
Concentration: 0.6 μM, 1.8 μM, 5.6 μM, 16.6 μM, and 50 μM
Incubation Time: 24 hours
Result: Resulted depletion of c-Myc in a dose-dependent manner.

Apoptosis Analysis[1]

Cell Line: Human leukemia MV-4-11 cells
Concentration: 5 μM, 10 μM, 20 μM
Incubation Time: 24 hours
Result: Induced cell apoptosis by arresting cell cycle at G1 phase.
Molecular Weight

397.49

Formula

C20H23N5O2S

CAS No.
SMILES

CN(C)CCCN1C=CC2=C1C=CC(C3=NC(S(C)(=O)=O)=NC4=C3C=CN4)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
DC-BPi-11
Cat. No.:
HY-141703
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