2568276-91-3

PROTAC SMARCA2/4-degrader-18 Chemical Structure
2568276-91-3

Chemical Structure

PROTAC SMARCA2/4-degrader-18

  • CAS No.: 2568276-91-3
  • Formula:C55H64N12O5S
  • Molecular Weight:1005.24

InChIKey: KJFUXRATVDHAPS-QRDMRLQQSA-N

SMILES: NC1=C(C=C(C2=C(C=CC=C2)O)N=N1)N3CC4N(C5=NC=C(C6CCN(CC6)CC7=CC=C(C=C7)C(N[C@@H](C(C)(C)C)C(N8[C@@H](C[C@H](C8)O)C(NCC9=CC=C(C%10=C(N=CS%10)C)C=C9)=O)=O)=O)C=N5)C(CC4)C3

Biological Activity: PROTAC SMARCA2/4-degrader-18 (Compound I-348) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-18 degrades SMARCA2 in A549 with DC50 <100 nM, degrades SMARCA4 in MV411 with DC50 <100 nM.

Cat. No. Product Name Purity Description Pricing
HY-163871 		PROTAC SMARCA2/4-degrader-18 PROTAC SMARCA2/4-degrader-18 (Compound I-348) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-18 degrades SMARCA2 in A549 with DC50 <100 nM, degrades SMARCA4 in MV411 with DC50 <100 nM.
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