Transmembrane Glycoprotein

Transmembrane glycoproteins are important components of cell membranes and are characterized by oligosaccharide chains covalently linked to polypeptide chains. Glycosylation sites are mainly located in their extracellular regions, achieved by N-linked glycosylation (linked to asparagine residues) or O-linked glycosylation (linked to serine or threonine residues). Sugar chains not only provide structural stability to proteins but also confer functional specificity. Many transmembrane glycoproteins are receptors, such as G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs). Most （clusters of differentiation）CD molecules are also transmembrane glycoproteins expressed on the surface of antigen-presenting cells^[1]^[2].

References:

[1]. L Franco, et al. The transmembrane glycoprotein CD38 is a catalytically active transporter responsible for generation and influx of the second messenger cyclic ADP-ribose across membranes. FASEB J. 1998 Nov;12(14):1507-20. [Content Brief]

[2]. Kumi Oshima, et al. SHPS-1, a multifunctional transmembrane glycoprotein. FEBS Lett. 2002 May 22;519(1-3):1-7. [Content Brief]

Transmembrane Glycoprotein Related Products (368):

By Effects:	Inhibitors (229) Agonists (7) Ligands (14) Antagonists (7) Activators (10) Modulators (5)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-P990846

Anti-Fy3 Antibody (MIMA-29)	Inhibitor
Anti-Fy3 Antibody (MIMA-29) is a kind of mouse IgG2a κ chimeric antibody inhibitor, targeting to human Fy3. Anti-Fy3 Antibody (MIMA-29) binds to erythrocytes and induces RBC (red blood cells) clearance. Anti-Fy3 Antibody (MIMA-29) can be used for the research of metabolic disease .

HY-P991576

Anti-CD326/EPCAM Antibody (3622W94)	Inhibitor
Anti-CD326/EPCAM Antibody (3622W94) is a humanized antibody expressed in CHO cells, targeting EpCAM/TROP1/CD326. Anti-CD326/EPCAM Antibody (3622W94) can be used for epithelial cancers research, such as pancreatic, prostate and breast cancer.

HY-P990163

Anti-Mouse Siglec-H Antibody (440c)	Inhibitor	98.45%
Anti-Mouse Siglec-H Antibody (440c) is a rat-derived IgG2b type antibody inhibitor, targeting to mouse Siglec-H. Anti-Mouse Siglec-H Antibody (440c) recognizes sialic acid-binding immunoglobulin (Ig)-like lectin family (Siglec-H) selectively expressing on plasmacytoid DCs and interferon–producing cells. Anti-Mouse Siglec-H Antibody (440c) can be used for the researches of inflammation and immunology, such as colitis.

HY-P991469

AMG-211	Inhibitor
AMG-211 (MEDI-565)i s a bispecific antibody targeting CD3E and CEACAM5/CEA/CD66e. AMG-211 can be used in Gastrointestinal cancer and Solid tumours research.

HY-P990266

Anti-Mouse CD48 Antibody (HM48-1)	Inhibitor
Anti-Mouse CD48 Antibody (HM48-1) is an Armenian hamster-derived IgG type antibody inhibitor, targeting to mouse CD48. Anti-Mouse CD48 Antibody (HM48-1) can block block the CD48/CD2 and CD48/CD244 interactions. Anti-Mouse CD48 Antibody (HM48-1) can be used for the researches of cancer, inflammation and immunology, such as myeloma and experimental autoimmune encephalomyelitis.

HY-P991517

BI-836858	Inhibitor
BI-836858 is a fully human anti-CD33 monoclonal antibody. BI-836858 reduces CD33+ cells via antibody-dependent cellular cytotoxicity (ADCC), blocks downstream signaling of S100A9/CD33, decreases the secretion of immunosuppressive cytokines and reactive oxygen species-induced genomic instability, and restores bone marrow hematopoietic function. BI-836858 is applicable to the research of myelodysplastic syndrome (MDS) and AML.

HY-P991893

Anti-CD5 Antibody (MAT 304)
Anti-CD5 Antibody (MAT 304) is an antibody against human CD5.

HY-P990834

Anti-MAGEC2/CT10 Antibody (LX-CT10.5)	Inhibitor
Anti-MAGEC2/CT10 Antibody (LX-CT10.5) is a kind of mouse IgG2a κ chimeric antibody, targeting to human MAGEC2/CT10. Anti-MAGEC2/CT10 Antibody (LX-CT10.5) reacts with human melanoma-associated antigen C2 (MAGEC2), also known as CT10. Anti-MAGEC2/CT10 Antibody (LX-CT10.5) can be used for identifying MAGEC2 expressing cells in immunohistochemistry, immunofluorescence and western blot studies.

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