Virus Protease
Viral proteases are enzymes encoded by the genetic material (DNA or RNA) of viral pathogens. Viral proteases catalyze the cleavage of specific peptide bonds in viral polyprotein precursors or in cellular proteins. Viral proteases may use different catalytic mechanisms involving either serine, cysteine or aspartic acid residues to attack the scissile peptide bond. Selective recognition of these sequence patterns by a complementary substrate binding site of the enzyme ensures a high degree of specific recognition and cleavage.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the cause of the respiratory illness coronavirus disease 2019 (COVID-19). Initial spike protein priming by transmembrane protease, serine 2 (TMPRSS2) is essential for entry of SARS-CoV-2. After a SARS-CoV-2 virion attaches to a target cell, the cell's protease TMPRSS2 cuts open the spike protein of the virus, exposing a fusion peptide.
All Product Categories
-
Virus Protease Related Products (404)
Related Products (404)
-
Antibodies (1)
-
Mergocriptine
0 ImagesCat. No.: HY-136967CAS No.: 81968-16-3Synonyms: CBM36-733Mergocriptine (CBM36-733) is a dopamine receptor agonist and SARS-CoV-2 Mpro ligand. Mergocriptine regulates ambulatory activity.
-
4E2RCat (Standard)
0 ImagesCat. No.: HY-100733RCAS No.: 432499-63-3
-
Koenine
0 ImagesCat. No.: HY-N15268CAS No.: 28200-63-7Koenine is a carbazole alkaloid. It is predicted that Koenine has strong binding affinity and inhibitory ability to SARS-CoV-2 main protease (Mpro), which can be used in the research of anti-novel coronavirus drugs.
-
ZHAWOC25153
0 ImagesCat. No.: HY-170504ZHAWOC25153 (Compound 17o) is a SARS-CoV-2 papain-like cysteine protease (PLpro) inhibitor, with an IC50 of 7 μM. ZHAWOC25153 exhibits antiviral activity and can be used in research within the field of anti-infection.
