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Tirapazamine (Synonyms: SR259075; SR4233; Win59075; SML 0552; SR 259075; Tirazone)

製品番号: HY-13767 純度: 99.73%
取扱説明書

Tirapazamine is an anticancer agent that shows selective cytotoxicity for hypoxic cells in solid tumors, thereby inducing single-and double-strand breaks in DNA, base damage, and cell death. Tirapazamine is an anticancer and bioreductive agent. Tirapazamine can enhance the cytotoxic effects of ionizing radiation in hypoxic cells.

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Tirapazamine 構造式

Tirapazamine 構造式

CAS 番号 : 27314-97-2

容量 価格(税別) 在庫状況 数量
無料サンプル (0.5-1 mg)   今すぐ申し込む  
Solution
10 mM * 1 mL in DMSO USD 87 在庫あり
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 87 在庫あり
Estimated Time of Arrival: December 31
Solid
50 mg USD 79 在庫あり
Estimated Time of Arrival: December 31
100 mg USD 145 在庫あり
Estimated Time of Arrival: December 31
200 mg USD 264 在庫あり
Estimated Time of Arrival: December 31
500 mg   お問い合わせ  
1 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 5 publication(s) in Google Scholar

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製品説明

Tirapazamine is an anticancer agent that shows selective cytotoxicity for hypoxic cells in solid tumors, thereby inducing single-and double-strand breaks in DNA, base damage, and cell death. Tirapazamine is an anticancer and bioreductive agent. Tirapazamine can enhance the cytotoxic effects of ionizing radiation in hypoxic cells[1][2].

体外実験

Tirapazamine (TPZ) is the optimal drug for combination therapy using Pba[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: SCC7 cells
Concentration: 1mg
Incubation Time: 24 h
Result: Showed synergism with Pba at ED50, ED90 and ED95.
体内実験

Tirapazamine (1mg; intravenously injected; twice at a 24-h interval) shows a synergetic effect to kill tumor cells because TPZ was activated under the hypoxic conditions that originated from the PDT with Pba and laser irradiation[1].
.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C3H/HeN mice[1].
Dosage: 1mg
Administration: Tirapazamine (1mg; intravenously injected; twice at a 24-h interval)
Result: Suppressed the tumors of mice by using laser irradiation.
臨床実験
分子量

178.15

分子式

C7H6N4O2

CAS 番号
SMILES

NC1=[N+]([O-])C2=CC=CC=C2[N+]([O-])=N1

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 62.5 mg/mL (350.83 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.6132 mL 28.0662 mL 56.1325 mL
5 mM 1.1226 mL 5.6132 mL 11.2265 mL
10 mM 0.5613 mL 2.8066 mL 5.6132 mL
*Please refer to the solubility information to select the appropriate solvent.
体内:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: 2.5 mg/mL (14.03 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (11.68 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (11.68 mM); Clear solution

*All of the co-solvents are available by MCE.
参考文献

純度: 99.73%

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× = ×
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製品名:
Tirapazamine
製品番号:
HY-13767
数量:
MCE 日本正規代理店: