27314-97-2
Chemical Structure
Tirapazamine
Synonym(s): SR259075; SR4233; Win59075; SML 0552; SR 259075; Tirazone
- CAS No.: 27314-97-2
- Formula:C7H6N4O2
- Molecular Weight:178.15
IUPAC Name: 3-aminobenzo[e][1,2,4]triazine 1,4-dioxide
InChIKey: ORYDPOVDJJZGHQ-UHFFFAOYSA-N
SMILES: NC1=[N+]([O-])C2=CC=CC=C2[N+]([O-])=N1
Biological Activity: Tirapazamine (SR259075) is an anticancer agent that shows selective cytotoxicity for hypoxic cells in solid tumors, thereby inducing single-and double-strand breaks in DNA, base damage, and cell death. Tirapazamine is an anticancer and bioreductive agent.Tirapazamine (SR259075) can enhance the cytotoxic effects of ionizing radiation in hypoxic cells[1][2].
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Tirapazamine | 99.02% | Tirapazamine (SR259075) is an anticancer agent that shows selective cytotoxicity for hypoxic cells in solid tumors, thereby inducing single-and double-strand breaks in DNA, base damage, and cell death. Tirapazamine is an anticancer and bioreductive agent.Tirapazamine (SR259075) can enhance the cytotoxic effects of ionizing radiation in hypoxic cells. | ||||||||||||||||||||
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Similarity Score 0.77
HY-24366Quindoxin -
Similarity Score 0.71
HY-100044SR 4330 -
Similarity Score 0.69
HY-131042NNMTi -
Similarity Score 0.68
HY-W007524R2-Aminoquinoline (Standard) -
Similarity Score 0.68
HY-33354RNitrochin (Standard) -
Similarity Score 0.68
HY-W001604Quinolin-5-amine -
Similarity Score 0.68
HY-W000494Isoquinolin-1-amine -
Similarity Score 0.68
HY-W0073178-Aminoquinoline -
Similarity Score 0.68
HY-W008059Isoquinolin-4-amine -
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References
- [1]. Cai TY, et al. Tirapazamine sensitizes hepatocellular carcinoma cells to topoisomerase I inhibitors via cooperative modulation of hypoxia-inducible factor-1α. Mol Cancer Ther. 2014 Mar;13(3):630-42. [Content Brief]
- [2]. Sliwinska J, et al. Tirapazamine-doxorubicin interaction referring to heart oxidative stress and Ca2? balance protein levels. Oxid Med Cell Longev. 2012;2012:890826. [Content Brief]
