2. Neuronal Signaling
  3. Sigma Receptor
  4. AB10

AB10 is a selective S1R antagonist. AB10 with Ki of 10, 165 nM for S1R and S2R, respectively. AB10 reverses the effect of Capsaicin (HY-10448) caused pain in model.

For research use only. We do not sell to patients.

AB10 Chemical Structure

AB10 Chemical Structure

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AB10 Related Antibodies

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Description

AB10 is a selective S1R antagonist. AB10 with Ki of 10, 165 nM for S1R and S2R, respectively. AB10 reverses the effect of Capsaicin (HY-10448) caused pain in model[1].

IC50 & Target[1]

Sigma 1 Receptor

10 nM (Ki)

Sigma 2 Receptor

165 nM (Ki)

In Vivo

AB10 (20 mg/kg, s.c., administered 30 min before the injection of capsaicin ) induced S1R antagonist effect to reverse pain and showed higher potency than BD-1063 (HY-18101A)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Capsaicin-induced as a pain model in CD1 mice[1]
Dosage: 20 mg/kg
Administration: subcutaneous injection performed in different areas of the interscapular zone, administered 30 min before the injection of Capsaicin (HY-10448).
Result: Achieved similar effects at half the concentration of BD-1063 (HY-18101A) (40mg/kg).
Showed complete reversal of the mechanical hypersensitivity reaction.
Molecular Weight

334.50

Formula

C23H30N2
SMILES

C1(CN(CC2=CC=CC=C2)C3)C3CCCN1CCCC4=CC=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AB10 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AB10AB 10AB-10Sigma ReceptorS1R antagonistCapsaicin-induced mechanical hypersensitivity.Inhibitorinhibitorinhibit

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HY-149855
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