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  4. Ac-Cys-Deruxtecan

Ac-Cys-Deruxtecan is a drug linker intermediate used in antibody-drug conjugate manufacturing.Ac-Cys-Deruxtecan reacts with reduced antibodies, and excess unreacted forms are quenched by thiol-containing reagents.

For research use only. We do not sell to patients.

Ac-Cys-Deruxtecan

Ac-Cys-Deruxtecan Chemical Structure

CAS No. : 2409510-92-3

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Ac-Cys-Deruxtecan Related Antibodies

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Description

Ac-Cys-Deruxtecan is a drug linker intermediate used in antibody-drug conjugate manufacturing.Ac-Cys-Deruxtecan reacts with reduced antibodies, and excess unreacted forms are quenched by thiol-containing reagents[1].

Molecular Weight

1197.25

Formula

C57H65FN10O16S
CAS No.
SMILES

O=C(C(CC1=O)SC[C@@H](C(O)=O)NC(C)=O)N1CCCCCC(NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(NCC(NCOCC(N[C@@H]3C4=C5C(C(N6C5)=CC([C@](O)(C(OC7)=O)CC)=C7C6=O)=NC8=CC(F)=C(C)C(CC3)=C84)=O)=O)=O)=O)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (83.52 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8352 mL 4.1762 mL 8.3525 mL
5 mM 0.1670 mL 0.8352 mL 1.6705 mL
View the Complete Stock Solution Preparation Table

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8352 mL 4.1762 mL 8.3525 mL 20.8812 mL
5 mM 0.1670 mL 0.8352 mL 1.6705 mL 4.1762 mL
10 mM 0.0835 mL 0.4176 mL 0.8352 mL 2.0881 mL
15 mM 0.0557 mL 0.2784 mL 0.5568 mL 1.3921 mL
20 mM 0.0418 mL 0.2088 mL 0.4176 mL 1.0441 mL
25 mM 0.0334 mL 0.1670 mL 0.3341 mL 0.8352 mL
30 mM 0.0278 mL 0.1392 mL 0.2784 mL 0.6960 mL
40 mM 0.0209 mL 0.1044 mL 0.2088 mL 0.5220 mL
50 mM 0.0167 mL 0.0835 mL 0.1670 mL 0.4176 mL
60 mM 0.0139 mL 0.0696 mL 0.1392 mL 0.3480 mL
80 mM 0.0104 mL 0.0522 mL 0.1044 mL 0.2610 mL
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Ac-Cys-Deruxtecan Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ac-Cys-Deruxtecan2409510-92-3Drug IntermediateDrug Iintermediateantibody-drug conjugatethiol-containing reagentsantibodiesInhibitorinhibitorinhibit

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