Afovirsen sodium
Afovirsen sodium is a 20-mer phosphorothioate oligonucleotide. It is complementary to the mRNA sequence for the translation initiation codon of the E2 protein vital to replication of HPV types 6 and 11.
For research use only. We do not sell to patients.
- CAS No.: 138330-98-0
- Formula: C192H250N57O107P19S19Na19
- Molecular Weight:6702.89
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Chemical Information
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CAS No. 138330-98-0
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Molecular Weight 6702.89
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Formula C192H250N57O107P19S19Na19
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SMILES
[Afovirsen (sodium)]
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Synonyms
ISIS 2105 sodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Crooke ST, Grillone LR, Tendolkar A, et al. A pharmacokinetic evaluation of 14C-labeled afovirsen sodium in patients with genital warts. Clin Pharmacol Ther. 1994;56(6 Pt 1):641-646. [Content Brief]
[2]. Crooke RM, Graham MJ, Cooke ME, Crooke ST. In vitro pharmacokinetics of phosphorothioate antisense oligonucleotides. J Pharmacol Exp Ther. 1995;275(1):462-473. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)