2. Protein Tyrosine Kinase/RTK
  3. Anaplastic lymphoma kinase (ALK)
  4. ALK-IN-34

ALK-IN-34 is an Anaplastic Lymphoma Kinase (ALK) inhibitor with an IC50 of 0.26 μM. ALK-IN-34 demonstrates antiproliferative activity against lung cancer cells and gastric adenocarcinoma cells.

For research use only. We do not sell to patients.

ALK-IN-34

ALK-IN-34 Chemical Structure

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ALK-IN-34 Related Antibodies

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Description

ALK-IN-34 is an Anaplastic Lymphoma Kinase (ALK) inhibitor with an IC50 of 0.26 μM. ALK-IN-34 demonstrates antiproliferative activity against lung cancer cells and gastric adenocarcinoma cells[1].

In Vitro

ALK-IN-34 (compound 8c) (1-100 μM; 72 h) potently inhibits proliferation of Karpas 299 cells (IC50 = 2.17 μM) and H2228 cells (IC50 = 6.02 μM), with lower potency against A549 and AGS cells[1].
ALK-IN-34 (10 μM) shows greater selectivity towards ALK but also significantly inhibits EGFR and VEGFR2 kinases at 10 μM[1].
ALK-IN-34 has lower toxicity towards L929 normal cells (IC50 = 102.2 μM) compared to Karpas 299 cancer cells, with a selectivity index of 47.09[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ALK-IN-34 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: Karpas 299 (NPM-ALK-positive ALCL), H2228 (EML4-ALK-positive NSCLC), A549 (ALK-negative NSCLC), AGS (gastric adenocarcinoma)
Concentration: 1, 5, 10, 25, 50, 100 μM
Incubation Time: 72 h
Result: Inhibited proliferation of Karpas 299 cells with an IC₅₀ of 2.17 μM, H2228 cells with an IC₅₀ of 6.02 μM, A549 cells with an IC₅₀ of 41 μM, and AGS cells with an IC₅₀ of 45.8 μM.
Molecular Weight

379.45

Formula

C25H21N3O
SMILES

COC(C=C1)=CC=C1C2=C3C(C4=CC=CC=C4CC3)=NC(NC5=CC=CC=C5)=N2
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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ALK-IN-34 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ALK-IN-34Anaplastic lymphoma kinase (ALK)Anaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246EGFR kinaseCDK2anaplastic large cell lymphomaKarpas 299 cellslung cancer cellsVEGFR2 kinaseH2228 cellsnon-small cell lung cancergastric adenocarcinoma cellsAnaplastic Lymphoma KinaseInhibitorinhibitorinhibit

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