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  4. Allo-aca

Allo-aca, a leptin peptidomimetic, is a potent, specific leptin receptor antagonist peptide. Allo-aca blocks leptin signaling and action in numerous in vitro and in vivo models.

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Allo-aca

Allo-aca 構造式

CAS 番号 : 3109368-53-5

容量 価格（税別） 在庫状況 数量
1 mg $450 在庫あり
5 mg $1250 在庫あり
10 mg $1990 在庫あり
50 mg   お問い合わせ  
100 mg   お問い合わせ  

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Based on 10 publication(s) in Google Scholar

Other Forms of Allo-aca:

Allo-aca 関連抗体

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Neuropeptide Y Receptor アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
NPY Y1 receptor NPY Y2 receptor NPY Y4 receptor NPY Y5 receptor

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製品説明

Allo-aca, a leptin peptidomimetic, is a potent, specific leptin receptor antagonist peptide. Allo-aca blocks leptin signaling and action in numerous in vitro and in vivo models[1][2].

体外実験

Allo-aca inhibits leptin-induced proliferation of MDA-MB-231 cells at 50 pM concentration. Allo-aca inhibits leptin-induced proliferation of MCF-7 cells with an IC50 of 200 pM[1].
Allo-aca at 250 nmol/L reduces VEGF-dependent leptin mRNA expression in both cell lines below base levels. Allo-aca inhibits VEGF mitogenic effects. Allo-aca inhibits VEGF-induced chemotaxis and chemokinesis in RF/6A retinal endothelial cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Allo-aca 関連抗体
体内実験

In an MDA-MB-231 orthotopic mouse xenograft model, Allo-aca administered subcutaneously significantly extends the average survival time from 15.4 days (untreated controls) to 24 and 28.1 days at 0.1 and 1mg/kg/day doses, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1074.19

分子式

C48H75N13O15
CAS 番号
Appearance

Solid

Color

White to off-white

Sequence

{H-allo}-Thr-Glu-{Nva}-Val-Ala-Leu-Ser-Arg-{Aca}-NH2
Sequence Shortening

{H-allo}-TE-{Nva}-VALSR-{Aca}-NH2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Sealed storage, away from moisture
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 50 mg/mL (46.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 50 mg/mL (46.55 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9309 mL 4.6547 mL 9.3093 mL
5 mM 0.1862 mL 0.9309 mL 1.8619 mL
10 mM 0.0931 mL 0.4655 mL 0.9309 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

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体積 （開始）

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.82%

COA (249 KB) RP-HPLC (251 KB) MS (70 KB) Elemental Analysis Report (106 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 0.9309 mL 4.6547 mL 9.3093 mL 23.2734 mL
5 mM 0.1862 mL 0.9309 mL 1.8619 mL 4.6547 mL
10 mM 0.0931 mL 0.4655 mL 0.9309 mL 2.3273 mL
15 mM 0.0621 mL 0.3103 mL 0.6206 mL 1.5516 mL
20 mM 0.0465 mL 0.2327 mL 0.4655 mL 1.1637 mL
25 mM 0.0372 mL 0.1862 mL 0.3724 mL 0.9309 mL
30 mM 0.0310 mL 0.1552 mL 0.3103 mL 0.7758 mL
40 mM 0.0233 mL 0.1164 mL 0.2327 mL 0.5818 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Allo-aca Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Allo-aca3109368-53-5Neuropeptide Y ReceptorOthersNPY receptortriple-negativebreastcancerMDA-MB-231glioblastomaInhibitorinhibitorinhibit

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製品名:
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製品番号:
HY-P3212
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