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Cat. No.: HY-183179

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α1A Adrenoceptor antagonist-1

α1A Adrenoceptor antagonist-1 is a selective α1A adrenoceptor antagonist with a human K_i <20 nM. α1A Adrenoceptor antagonist-1 exhibits activity against benign prostatic hyperplasia (BPH) to enable less hindered urine flow. α1A Adrenoceptor antagonist-1 relaxes α1a receptor-enriched urethral smooth muscle tissue without inducing hypotension. α1A Adrenoceptor antagonist-1 can be used for the research of benign prostatic hyperplasia (BPH).

For research use only. We do not sell to patients.

CAS No.: 359722-12-6
Formula: C₃₄H₃₄ClF₃N₄O₄
Molecular Weight:655.11

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

α1A Adrenoceptor antagonist-1 Chemical Structure

CAS No.: 359722-12-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

α1A-adrenergic receptor

<20 nM (Ki)

All Adrenergic Receptor Isoforms :

In Vitro

α₁A Adrenoceptor antagonist-1 (Compound 29) (Increasing amounts of unlabeled ligand; 1 hour) binds to the human α₁A adrenoceptor cell line with a K_i value of less than 20 nM^[1].
α₁A Adrenoceptor antagonist-1 exhibits at least 10-fold selective binding to the human α₁A adrenoceptor cell line relative to human α₁B adrenoceptor and α₁D adrenoceptor cell lines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 359722-12-6
Molecular Weight 655.11
Formula C₃₄H₃₄ClF₃N₄O₄
SMILES

O=C1OC2(CCN(CC2)CCCN3C(NC(C4=CC=C(C)C=C4)(C5=CC=C(C)C=C5)C3=O)=O)C6=CC(Cl)=CC=C6N1CC(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Mark G Bock, et al. Novel arylhydantoin derivatives useful as alpha 1a adrenoceptor antagonists. GB2355456A. 2001-04-25

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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α1A Adrenoceptor antagonist-1

All Adrenergic Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

α1A Adrenoceptor antagonist-1 Related Classifications

HY-183179 Related Classifications