α1A Adrenoceptor antagonist-1
α1A Adrenoceptor antagonist-1 is a selective α1A adrenoceptor antagonist with a human Ki <20 nM. α1A Adrenoceptor antagonist-1 exhibits activity against benign prostatic hyperplasia (BPH) to enable less hindered urine flow. α1A Adrenoceptor antagonist-1 relaxes α1a receptor-enriched urethral smooth muscle tissue without inducing hypotension. α1A Adrenoceptor antagonist-1 can be used for the research of benign prostatic hyperplasia (BPH).
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- No. CAS: 359722-12-6
- Fòrmula: C34H34ClF3N4O4
- Peso molecular:655.11
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
α1A-adrenergic receptor <20 nM (Ki) |
In Vitro
α1A Adrenoceptor antagonist-1 (Compound 29) (Increasing amounts of unlabeled ligand; 1 hour) binds to the human α1A adrenoceptor cell line with a Ki value of less than 20 nM[1].
α1A Adrenoceptor antagonist-1 exhibits at least 10-fold selective binding to the human α1A adrenoceptor cell line relative to human α1B adrenoceptor and α1D adrenoceptor cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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No. CAS 359722-12-6
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Peso molecular 655.11
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Fòrmula C34H34ClF3N4O4
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SMILES
O=C1OC2(CCN(CC2)CCCN3C(NC(C4=CC=C(C)C=C4)(C5=CC=C(C)C=C5)C3=O)=O)C6=CC(Cl)=CC=C6N1CC(F)(F)F
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
α1A Adrenoceptor antagonist-1 Related Classifications
HY-183179 Related Classifications
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