α1A Adrenoceptor antagonist-1 

α1A Adrenoceptor antagonist-1 is a selective α1A adrenoceptor antagonist with a human K_i <20 nM. α1A Adrenoceptor antagonist-1 exhibits activity against benign prostatic hyperplasia (BPH) to enable less hindered urine flow. α1A Adrenoceptor antagonist-1 relaxes α1a receptor-enriched urethral smooth muscle tissue without inducing hypotension. α1A Adrenoceptor antagonist-1 can be used for the research of benign prostatic hyperplasia (BPH)^[1].

α₁A Adrenoceptor antagonist-1 (Compound 29) (Increasing amounts of unlabeled ligand; 1 hour) binds to the human α₁A adrenoceptor cell line with a K_i value of less than 20 nM^[1].
α₁A Adrenoceptor antagonist-1 exhibits at least 10-fold selective binding to the human α₁A adrenoceptor cell line relative to human α₁B adrenoceptor and α₁D adrenoceptor cell lines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

655.11

C₃₄H₃₄ClF₃N₄O₄

359722-12-6

O=C1OC2(CCN(CC2)CCCN3C(NC(C4=CC=C(C)C=C4)(C5=CC=C(C)C=C5)C3=O)=O)C6=CC(Cl)=CC=C6N1CC(F)(F)F

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• [1]. Mark G Bock, et al. Novel arylhydantoin derivatives useful as alpha 1a adrenoceptor antagonists. GB2355456A. 2001-04-25