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Cat. No.: HY-181094

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α-Glucosidase-IN-110

α-Glucosidase-IN-110 is a selective and orally active competitive inhibitor of α-Glucosidase with an IC₅₀ of 7.09 μM and a K_i of 6.9 μM. α-Glucosidase-IN-110 can reduce fasting blood glucose levels, improve glucose tolerance, and restore the histomorphology of liver and pancreatic tissues in diabetic rat models. α-Glucosidase-IN-110 can be used for the research of diabetes.

For research use only. We do not sell to patients.

Formula: C₂₆H₂₁ClN₆O₂S
Molecular Weight:517.00

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

α-Glucosidase-IN-110 Chemical Structure

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Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

α-Glucosidase-IN-110 (Compound 15o) (up to 100 μM) shows no significant cytotoxicity toward HDF and L929 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

α-Glucosidase-IN-110 (Compound 15o) (5-30 mg/kg; p.o.; 28 days) exhibits dose-dependent antidiabetic effects in diabetic rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Diabetic rats^[1]
Dosage:

5, 15, 30 mg/kg
Administration:

p.o.; daily; 28 days
Result:

Normalized fasting blood glucose levels.
Improved glucose tolerance in OGTT.
Reduced HbA₁c levels to near-normal ranges.
Restored nearly normal liver architecture and pancreatic islet architecture.

Chemical Information

Molecular Weight 517.00
Formula C₂₆H₂₁ClN₆O₂S
SMILES

ClC(C=C1)=CC=C1C2=C(N)C(C3=CC=C(OC)C=C3)=NC4=NC(SCC(NC5=CC=CC=C5)=O)=NN24
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Peytam F, et al. Design, synthesis, and antidiabetic evaluation of triazolopyrimidine thioacetamides as potent and selective α-glucosidase inhibitors. Bioorg Chem. 2026;170:109482. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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