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Cat. No.: HY-187565

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Androgen receptor ligand 5

Androgen receptor ligand 5 (Compound 7) is an Androgen receptor ligand. Androgen receptor ligand 5 can serve as a target protein ligand for the synthesis of HEMTAC AR degraders, such as HEMTAC AR degrader-1 (HY-187229). Androgen receptor ligand 5 can be used for research on prostate cancer.

For research use only. We do not sell to patients.

CAS No.: 1189135-60-1
Formula: C₂₁H₁₆F₃N₃O₂
Molecular Weight:399.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Androgen receptor ligand 5 Chemical Structure

CAS No.: 1189135-60-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All Hsp-targeting Chimeras Isoforms :

Chemical Information

CAS No. 1189135-60-1
Molecular Weight 399.37
Formula C₂₁H₁₆F₃N₃O₂
SMILES

OC(C1=CC=C(CC2=C(C)N(C3=CC=C(C#N)C(C(F)(F)F)=C3)N=C2C)C=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Signal Pathway Related

Research Protocol for Endocrine Diseases
Endocrine diseases often arise from disrupted hormone production, hormone signaling, or target-tissue responsiveness; for diabetes-focused endocrine disease models, insulin signaling regulates glucose uptake, hepatic glucose output, lipid metabolism, and β-cell compensation. Type 2 diabetes develops through interacting defects in insulin resistance, β-cell dysfunction, adipose inflammation, hepatic glucose overproduction, altered incretin signaling, and ectopic lipid metabolism. A major unresolved question is whether endocrine dysfunction is driven primarily by target-tissue insulin resistance, intrinsic β-cell failure, immune/inflammatory stress, or combined multi-organ failure that differs by disease stage.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Li Z, et al. Design, synthesis, and biological evaluation of HSP70-mediated HEMTACs as novel androgen receptor degraders. European journal of medicinal chemistry. 2026 Nov 05;317:119107. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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