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Cat. No.: HY-151925

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Antibacterial agent 126

Antibacterial agent 126 is a potent antibacterial agent. Antibacterial agent 126 reduces the burden of biofilm to avoid developing agent resistance. Antibacterial agent 126 disturbs the membrane integrity and leads to the leakage of intracellular materials. Antibacterial agent 126 increase in ROS and reactive nitrogen species (RNS) production.

For research use only. We do not sell to patients.

Formula: C₂₁H₂₄NO₆P
Molecular Weight:417.39

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Antibacterial agent 126 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Antibacterial agent 126 (compoud 6f) shows antibacterial activity with MIC values of 0.5, 4 μg/mL for staphylococcus aureus, escherichia coli ATCC 25922, respectively^[1].
Antibacterial agent 126 (0-256 μg/mL; 0-8 h) shows low hemolytic activity to RBCs^[1].
Antibacterial agent 126 (0.5, 1, 2, 4, 8 μg/mL) effectively disrupts the bacterial biofilm, decreases the biofilm viability and increases in protein leakage from bacterial cells interacting with molecule in a dose-dependent manner in staphylococcus aureus^[1].
Antibacterial agent 126 (0.5, 1, 2, 4 μg/mL) increase in ROS and reactive nitrogen species (RNS) production in a dose dependent manner in staphylococcus aureus^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 417.39
Formula C₂₁H₂₄NO₆P
SMILES

CC(C1=CC=C(C=C1O2)NC(P(OCC)(OCC)=O)C3=CC=CC(O)=C3)=CC2=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yang XC, et al. Novel coumarin aminophosphonates as potential multitargeting antibacterial agents against Staphylococcus aureus. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114891. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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