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Cat. No.: HY-187345

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Antibacterial agent 364

Antibacterial agent 364 is an antibacterial agent. Antibacterial agent 364 inhibits the expression of the hrpY gene and downregulates the expression of prhG, phcA, prhA and prhR. Antibacterial agent 364 impairs the swimming motility of Ralstonia solanacearum, suppresses the T3SS-related regulatory network, and attenuates the virulence of Ralstonia solanacearum without inhibiting bacterial growth. Antibacterial agent 364 is applicable to studies related to plant infections.

For research use only. We do not sell to patients.

CAS No.: 2293958-34-4
Formula: C₁₇H₁₅ClN₂O₂S
Molecular Weight:346.83

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Please store the product under the recommended conditions in the Certificate of Analysis.

Antibacterial agent 364 Chemical Structure

CAS No.: 2293958-34-4

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Biological Activity
- Description
- In Vitro
Chemical Information
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Bioz

Biological Activity

Description

In Vitro

Antibacterial agent 364 (compound W40) (100 μM; 8 h) potently inhibits transcription driven by the hrpY promoter in Ralstonia solanacearum GMI1000, with an inhibition rate of 96.45%, without affecting bacterial growth^[1].
Antibacterial agent 364 (100 μM) inhibits the expression of prhG, prhA, prhR, phcA and ripW genes in Ralstonia solanacearum GMI1000, but does not alter the expression of other tested T3SS regulatory genes, virulence-related genes and effector protein genes^[1].
Antibacterial agent 364 (100 μM; 72 h) impairs the swimming motility of Ralstonia solanacearum GMI1000 following incubation on semi-solid assay plates^[1].
Antibacterial agent 364 (100 μM) has no effect on biofilm formation, extracellular polysaccharide production, or cellulase activity of Ralstonia solanacearum GMI1000^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2293958-34-4
Molecular Weight 346.83
Formula C₁₇H₁₅ClN₂O₂S
SMILES

CC1=CC=C(C=C1)CSC2=NN=C(C(C3=CC=C(Cl)C=C3)O)O2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Guo Q, et al. Novel Mandelic Acid Derivatives Containing 1,3,4-Oxadiazolyl Thioether for Enhancing Antibacterial Potential against Ralstonia solanacearum. Journal of Agricultural and Food Chemistry, 2026, 74(27): 20944-20953.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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