2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies
  5. ABCC5 Antibody (YA7785)

ABCC5 Antibody (YA7785) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ABCC5.

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容量 価格（税別） 在庫状況
20 μL $115 見積もりとリードタイムを求めるのご確認
50 μL $185 見積もりとリードタイムを求めるのご確認
100 μL $300 見積もりとリードタイムを求めるのご確認

* アイテムを追加する前、数量をご選択ください

Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • 説明

製品説明

ABCC5 Antibody (YA7785) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ABCC5.
Host

Mouse
Clonality

Monoclonal
分子量

Predicted band size: 23.5 kDa
Species Reactivity
Human, Mouse, Rat
SwissProt ID
Immunogen

Full length human recombinant protein of human ABCC5 produced in E.coli.
Application &
Dilution Ratio
Application Dilution Ratio
IHC-P
IHC-P: Immunohistochemistry-Paraffin
1:150-500
Sensitivity Endogenous 純度 Affinity purified
Conjugation Non-conjugated Modification Unmodified
Isotype IgG1  
Appearance

Liquid
Formulation

Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
輸送条件

Shipping with blue ice.
Background
Function：ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of endogenous metabolites such as cAMP and cGMP, folic acid and N-lactoyl-amino acids (in vitro) (PubMed:10893247, PubMed:12637526, PubMed:12695538, PubMed:15899835, PubMed:17229149, PubMed:25964343). Also acts as a general glutamate conjugate and analog transporter that can limit the brain levels of endogenous metabolites, drugs, and toxins (PubMed:26515061). Confers resistance to the antiviral agent PMEA (PubMed:12695538). Able to transport several anticancer drugs including methotrexate, and nucleotide analogs in vitro, however it does with low affinity, thus the exact role of ABCC5 in mediating resistance still needs to be elucidated (PubMed:10840050, PubMed:12435799, PubMed:12695538, PubMed:15899835). Acts as a heme transporter required for the translocation of cytosolic heme to the secretory pathway (PubMed:24836561). May play a role in energy metabolism by regulating the glucagon-like peptide 1 (GLP-1) secretion from enteroendocrine cells (By similarity)
Subcellular Localization：Basolateral cell membrane,Golgi apparatus lumen,Endosome membrane,Cytoplasmic granule,Apical cell membrane
Expression：
Tissue_Specificity: Predominant isoform in retinal pigment epithelium, bladder, and stomach|Ubiquitously expressed, but levels in brain and muscle are especially high (PubMed:10438534, PubMed:15501592, PubMed:9827529). All isoforms are equally expressed in retina (PubMed:17521428)
Isoforms & Post-Translational Modification：O15440 has 5 isomers: O15440-1: 160660 Da (predicted); O15440-2: 25341 Da (predicted); O15440-3: 23988 Da (predicted); O15440-4: 23677 Da (predicted); O15440-5: 155732 Da (predicted).
Synonyms
ABC33; EST277145; MOAT-C; MOATC; MRP5; pABC11; SMRP
ドキュメンテーション
User Guide for Antibodies (1077 KB)

ABCC5 Antibody (YA7785) 関連分類

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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製品名:
ABCC5 Antibody (YA7785)
製品番号:
HY-P88101
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