ABCC5 Antibody (YA7785)
(Synonyms: ABC33; EST277145; MOAT-C; MOATC; MRP5; pABC11; SMRP)ABCC5 Antibody (YA7785) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ABCC5.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:150-500 |
Product Details
ABCC5 Antibody (YA7785) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ABCC5.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 23.5 kDa
Full length human recombinant protein of human ABCC5 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
ABCC5 is an ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of endogenous metabolites such as cAMP and cGMP, folic acid and N-lactoyl-amino acids (in vitro). Also acts as a general glutamate conjugate and analog transporter that can limit the brain levels of endogenous metabolites, drugs, and toxins. Confers resistance to the antiviral agent PMEA. Able to transport several anticancer drugs including methotrexate, and nucleotide analogs in vitro, however it does with low affinity, thus the exact role of ABCC5 in mediating resistance still needs to be elucidated. Acts as a heme transporter required for the translocation of cytosolic heme to the secretory pathway. May play a role in energy metabolism by regulating the glucagon-like peptide 1 (GLP-1) secretion from enteroendocrine cells[1][2][3][4][5][6][7][8][9][10].
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Subcellular Localization
Basolateral cell membrane,Golgi apparatus lumen,Endosome membrane,Cytoplasmic granule,Apical cell membrane
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Expression
Tissue_Specificity: Predominant isoform in retinal pigment epithelium, bladder, and stomach|Ubiquitously expressed, but levels in brain and muscle are especially high (PubMed:10438534, PubMed:15501592, PubMed:9827529). All isoforms are equally expressed in retina (PubMed:17521428) -
Isoforms & Post-Translational Modification
O15440 has 5 isomers: O15440-1: 160660 Da (predicted); O15440-2: 25341 Da (predicted); O15440-3: 23988 Da (predicted); O15440-4: 23677 Da (predicted); O15440-5: 155732 Da (predicted).
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SwissProt ID
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Synonyms
ABC33; EST277145; MOAT-C; MOATC; MRP5; pABC11; SMRP
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