Adenosine Deaminase Antibody (YA2607)(PBS only)
(Synonyms: ada; ADA1)Adenosine Deaminase Antibody (YA2607) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Adenosine Deaminase.
-
Host:
Rabbit
-
Isotype:
IgG
-
Application:
WB
-
Reactivity :
Human, Rat
-
Formulation:
Supplied in PBS, pH 7.4.
-
Conjugation:
Non-conjugated
Applications
| Application |
WB
WB: Western Blot
|
|---|---|
| Dilution Ratio | 1:1000-1:5000 |
Product Details
Adenosine Deaminase Antibody (YA2607) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Adenosine Deaminase.
-
Host Rabbit
-
Species ReactivityHuman, Rat
-
Observed Molecular WeightObserved band size: 41 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
-
Calculated Molecular Weight Predicted band size: 41 kDa
A synthesized peptide derived from human ADA
Affinity Purified
Non-conjugated
IgG
Product Properties
-
Appearance
Liquid
-
Formulation
Supplied in PBS, pH 7.4.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
선적
Shipping with blue ice.
Background
-
Function
Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine (PubMed:16670267, PubMed:23193172, PubMed:26166670, PubMed:8452534, PubMed:9361033). Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4 (PubMed:20959412). Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion (PubMed:11772392). Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion (By similarity). Enhances CD4+ T-cell differentiation and proliferation (PubMed:20959412). Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change (PubMed:23193172). Stimulates plasminogen activation (PubMed:15016824). Plays a role in male fertility (PubMed:21919946, PubMed:26166670). Plays a protective role in early postimplantation embryonic development (By similarity). Also responsible for the deamination of cordycepin (3'-deoxyadenosine), a fungal natural product that shows antitumor, antibacterial, antifungal, antivirus, and immune regulation properties (PubMed:26038697)
-
Subcellular Localization
Cell membrane; Peripheral membrane protein; Extracellular side; Cell junction; Cytoplasmic vesicle lumen; Cytoplasm; Lysosome
-
Expression
Tissue_specificity:Found in all tissues, occurs in large amounts in T-lymphocytes (PubMed:20959412) . Expressed at the time of weaning in gastrointestinal tissues
Induction:Up-regulated by hypoxia -
Subunit
Interacts with DPP4 (via extracellular domain) (PubMed:10951221, PubMed:14691230, PubMed:15016824, PubMed:7907293, PubMed:8101391). Interacts with PLG (via Kringle 4 domain); the interaction stimulates PLG activation when in complex with DPP4 (PubMed:15016824)
-
SwissProt ID
-
Synonyms
ada; ADA1
-
Research Field
Epigenetics and Nuclear Signaling
각종 서류
Powered by Bioz
