Adenosine Deaminase Antibody (YA2607)(PBS only)
(Synonyms: ada; ADA1)Adenosine Deaminase Antibody (YA2607) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Adenosine Deaminase.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human, Rat
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:1000-1:5000 |
Product Details
Adenosine Deaminase Antibody (YA2607) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Adenosine Deaminase.
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Host Rabbit
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Species ReactivityHuman, Rat
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Observed Molecular WeightObserved band size: 41 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 41 kDa
A synthesized peptide derived from human ADA
Affinity Purified
Non-conjugated
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Adenosine deaminase (ADA) is an enzyme of the purine metabolism which catalyzes the irreversible deamination of adenosine and deoxyadenosine to inosine and deoxyinosine, respectively. This ubiquitous enzyme has been found in a wide variety of microorganisms, plants, and invertebrates. In addition, it is present in all mammalian cells that play a central role in the differentiation and maturation of the lymphoid system. Two distinct adenosine deaminases, ADA1 and ADA2, are found in humans. ADA1 has an important role in lymphocyte function and inherited mutations in ADA1 result in severe combined immunodeficiency. ADA2 belongs to the novel family of adenosine deaminase growth factors (ADGFs), which play an important role in tissue development. ADA plays a critical role in various diseases. Interestingly, Both genetic ADA deficiency and ADA overexpression may cause diseases. Generally appreciated is the notion that inherited genetic ADA deficiency represents the main cause of severe combined immunodeficiency disease (SCID), accounting for about 15% of all SCID cases. Conversely, overexpression of ADA may be closely related to hemolytic anemia, liver cancer, breast cancer, etc.
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Subcellular Localization
Cell membrane; Peripheral membrane protein; Extracellular side; Cell junction; Cytoplasmic vesicle lumen; Cytoplasm; Lysosome
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Expression
Tissue_specificity:Found in all tissues, occurs in large amounts in T-lymphocytes (PubMed:20959412) . Expressed at the time of weaning in gastrointestinal tissues
Induction:Up-regulated by hypoxia -
Subunit
Interacts with DPP4 (via extracellular domain) (PubMed:10951221, PubMed:14691230, PubMed:15016824, PubMed:7907293, PubMed:8101391). Interacts with PLG (via Kringle 4 domain); the interaction stimulates PLG activation when in complex with DPP4 (PubMed:15016824)
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SwissProt ID
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Synonyms
ada; ADA1
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Research Field
Epigenetics and Nuclear Signaling
Documentation
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