ARHGEF12 Antibody
(Synonyms: KIAA0382, LARG, ARHGEF12, Rho guanine nucleotide exchange factor 12, Leukemia-associated RhoGEF)ARHGEF12 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to ARHGEF12.
-
Host:
Rabbit
-
Isotype:
IgG
-
Application:
WB, IHC-P
-
Reactivity :
Human, Mouse, Rat
-
Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
IHC-P
IHC-P: Immunohistochemistry-Paraffin
|
|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 |
Product Details
ARHGEF12 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to ARHGEF12.
-
Host Rabbit
-
Clonality Polyclonal
-
Species ReactivityHuman, Mouse, Rat
-
Observed Molecular WeightObserved band size: 200 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
-
Calculated Molecular Weight Predicted band size: 173 kDa
Synthetic peptide corresponding to the center region of human ARHGEF12.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
-
Appearance
Solution
-
Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
ARHGEF12 acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Promotes endothelial cell and actin stress fiber reorientation in response to mechanotransduction (By similarity)[1].
-
Subcellular Localization
Cytoplasm; Membrane
-
Expression
Tissue_Specificity: Ubiquitously expressed. Isoform 2 is found in jejunum and testis. -
Isoforms & Post-Translational Modification
ARHGEF12 has 2 isoforms, Q9NZN5-1: amino acid length is 1544, molecular weight is 173232 Da (predicted); Q9NZN5-2: amino acid length is 1525, molecular weight is 171115 Da (predicted).
-
Subunit
Interacts (probably via RGSL domain) with GNA12 and GNA13.
-
SwissProt ID
-
Synonyms
KIAA0382, LARG, ARHGEF12, Rho guanine nucleotide exchange factor 12, Leukemia-associated RhoGEF
Documentation
References
Powered by Bioz
