AZI2 Antibody (YA2226)
(Synonyms: AZ2; NAP1; TILP)AZI2 Antibody (YA2226) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AZI2.
-
Host:
Rabbit
-
Isotype:
IgG
-
Application:
WB
-
Reactivity :
Human, Rat
-
Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
|---|---|
| Dilution Ratio | 1:500-1:1000 |
Product Details
AZI2 Antibody (YA2226) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AZI2.
-
Host Rabbit
-
Clonality Recombinant, Monoclonal
-
Species ReactivityHuman, Rat
-
Observed Molecular WeightObserved band size: 45 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
-
Calculated Molecular Weight Predicted band size: 45 kDa
Recombinant protein of human AZI2
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
-
Appearance
Liquid
-
Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
AZI2 is an Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1[1][2][3].
-
Subcellular Localization
Cytoplasm
-
Expression
Tissue_specificity:Widely expressed (PubMed:14560022) . Abundant expression seen in the pancreas and testis (PubMed:14560022) -
Isoforms & Post-Translational Modification
Q9H6S1 has 4 isomers: Q9H6S1-1: 44935 Da (predicted); Q9H6S1-3: 26510 Da (predicted); Q9H6S1-4: 28188 Da (predicted); Q9H6S1-5: 26921 Da (predicted).
Ubiquitinated via 'Lys-48'-linked polyubiquitination by TRIM38, leading to its degradation -
Subunit
Homodimer (By similarity). Interacts with IKBKE (PubMed:14560022, PubMed:17568778). Interacts with TBK1 (PubMed:14560022, PubMed:21931631, PubMed:29251827). Interacts with TICAM1 (PubMed:15611223).
-
SwissProt ID
-
Synonyms
AZ2; NAP1; TILP
-
Research Field
Signal Transduction
Documentation
Powered by Bioz
