BCCIP Antibody
(Synonyms: TOK1, BCCIP, BRCA2 and CDKN1A-interacting protein, P21- and CDK-associated protein 1, Protein TOK-1)BCCIP Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to BCCIP.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 |
Product Details
BCCIP Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to BCCIP.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 50 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 33; 35; 36 kDa
Purified recombinant protein of human BCCIP
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
BCCIP is during interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole. Isoform 2/alpha is particularly important for the regulation of microtubule anchoring, microtubule stability, spindle architecture and spindle orientation, compared to isoform 1/beta. May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ)[1].
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Subcellular Localization
Nucleus; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole; Cytoplasm, cytoskeleton, spindle pole
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Expression
Tissue_Specificity: Expressed at high levels in testis and skeletal muscle and at lower levels in brain, heart, kidney, liver, lung, ovary, pancreas, placenta, and spleen. -
Isoforms & Post-Translational Modification
BCCIP has 4 isoforms, Q9P287-1: amino acid length is 314, molecular weight is 35979 Da (predicted); Q9P287-2: amino acid length is 322, molecular weight is 36215 Da (predicted); Q9P287-3: amino acid length is 292, molecular weight is 33442 Da (predicted); Q9P287-4: amino acid length is 292, molecular weight is 33242 Da (predicted).BCCIP 存在 4 个异构体，Q9P287-1：氨基酸个数为 314 个，分子量为 35979 Da (预测)；Q9P287-2：氨基酸个数为 322 个，分子量为 36215 Da (预测)；Q9P287-3：氨基酸个数为 292 个，分子量为 33442 Da (预测)；Q9P287-4：氨基酸个数为 292 个，分子量为 33242 Da (预测)。
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Subunit
Interacts with BRCA2, CDKN1A and MTDH/LYRIC.
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SwissProt ID
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Synonyms
TOK1, BCCIP, BRCA2 and CDKN1A-interacting protein, P21- and CDK-associated protein 1, Protein TOK-1
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