C2 Antibody (YA8041)

Cat. No.: HY-P88357: Data Sheet User Guide for Antibodies
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C2 Antibody (YA8041) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to C2.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

C2 Antibody (YA8041) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to C2.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 81 kDa

Species Reactivity

Human

SwissProt ID

P06681

Immunogen

Human recombinant protein fragment corresponding to amino acids 469-752 of human C2 produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:150-500

Sensitivity	Endogenous	Purity	Affinity purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG1

Appearance

Liquid

Formulation

Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Precursor of the catalytic component of the C3 and C5 convertase complexes, which are part of the complement pathway, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:12878586, PubMed:17027507, PubMed:18204047, PubMed:39914456). Component C2 is part of the classical, lectin and GZMK complement systems (PubMed:12878586, PubMed:17027507, PubMed:18204047, PubMed:39914456)|Catalytic component of the complement C3 and C5 convertase complexes (PubMed:12878586, PubMed:17027507, PubMed:18204047, PubMed:6906228). Following complement activation, recruited to the surface of pathogens by complement C4b opsonin to form the C3 convertase, or C3b and C4b opsonins to form the C5 convertase (PubMed:6611150, PubMed:6906228). As part of the C3 convertase, cleaves and activate C3 into C3a anaphylatoxin and C3b opsonin, the next components of the complement pathways (PubMed:14561755, PubMed:17027507). As part of the C5 convertase, cleaves and activate C5 into C5a anaphylatoxin and C5b component of the membrane attack complex (PubMed:12878586, PubMed:17027507, PubMed:18204047)

Subcellular Localization：Secreted,Cell surface

Isoforms & Post-Translational Modification：P06681 has three isomers: P06681-1: 83268 Da (predicted); P06681-2: 60318 Da (predicted); P06681-3: 69444 Da (predicted).
Cleaved and activated by different proteases depending on the complement pathway to generate complement C2a and serine protease complement C2b chains (PubMed:6282646, PubMed:6319179, PubMed:6906228, PubMed:70787)

Subunit：Serine protease component of the C3 convertase, also named C4bC2b, composed of the serine protease complement C2b and complement C4b (PubMed:14561755, PubMed:27252379, PubMed:3874204, PubMed:6611150, PubMed:6906228)

Synonyms

ARMD14; CO2

Documentation

User Guide for Antibodies (1077 KB)