C2 Antibody (YA8041)
(Synonyms: ARMD14; CO2)C2 Antibody (YA8041) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to C2.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P
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Reactivity :
Human
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:150-500 |
Product Details
C2 Antibody (YA8041) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to C2.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 81 kDa
Human recombinant protein fragment corresponding to amino acids 469-752 of human C2 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
C2 is a Precursor of the catalytic component of the C3 and C5 convertase complexes, which are part of the complement pathway, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Component C2 is part of the classical, lectin and GZMK complement systems |Catalytic component of the complement C3 and C5 convertase complexes. Following complement activation, recruited to the surface of pathogens by complement C4b opsonin to form the C3 convertase, or C3b and C4b opsonins to form the C5 convertase. As part of the C3 convertase, cleaves and activate C3 into C3a anaphylatoxin and C3b opsonin, the next components of the complement pathways. As part of the C5 convertase, cleaves and activate C5 into C5a anaphylatoxin and C5b component of the membrane attack complex[1][2][3][4][5][6][7].
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Subcellular Localization
Secreted,Cell surface
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Isoforms & Post-Translational Modification
P06681 has three isomers: P06681-1: 83268 Da (predicted); P06681-2: 60318 Da (predicted); P06681-3: 69444 Da (predicted).
Cleaved and activated by different proteases depending on the complement pathway to generate complement C2a and serine protease complement C2b chains (PubMed:6282646, PubMed:6319179, PubMed:6906228, PubMed:70787) -
Subunit
Serine protease component of the C3 convertase, also named C4bC2b, composed of the serine protease complement C2b and complement C4b (PubMed:14561755, PubMed:27252379, PubMed:3874204, PubMed:6611150, PubMed:6906228)
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SwissProt ID
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Synonyms
ARMD14; CO2
Documentation
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