C4b Antibody (YA9980)
(Synonyms: CO4, CPAMD3, C4B_2, C4B, Complement C4-B, Basic complement C4, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3)C4b Antibody (YA9980) is a Rabbit-derived and non-conjugated IgG Monoclonal, Recombinant antibody, targeting to C4b.
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Host:
Rabbit
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Isotype:
IgG
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Application:
IHC-P
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Reactivity :
Human
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Formulation:
Supplied in PBS (pH 7.4), containing 50% glycerol, 0.05% BSA and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:100-500 |
Product Details
C4b Antibody (YA9980) is a Rabbit-derived and non-conjugated IgG Monoclonal, Recombinant antibody, targeting to C4b.
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Host Rabbit
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Clonality Monoclonal,Recombinant
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Species ReactivityHuman
Purified recombinant protein of human C4b.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 50% glycerol, 0.05% BSA and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
C4b is a Precursor of non-enzymatic components of the classical, lectin and GZMK complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system
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Subcellular Localization
Secreted; Synapse; Cell projection, axon; Cell projection, dendrite
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Expression
Tissue_Specificity: Complement component C4 is expressed at highest levels in the liver, at moderate levels in the adrenal cortex, adrenal medulla, thyroid gland, and the kidney, and at lowest levels in the heart, ovary, small intestine, thymus, pancreas and spleen. The extra-hepatic sites of expression may be important for the local protection and inflammatory response. -
Isoforms & Post-Translational Modification
C4b has an amino acid length of 1744, molecular weight is 192751 Da.
Prior to secretion, the single-chain precursor is enzymatically cleaved by plasminogen (PLG) to yield non-identical chains alpha, beta and gamma (By similarity). During activation of the complement systems, the alpha chain is cleaved into C4a and C4b by different proteases depending on the complement pathway: C4b stays linked to the beta and gamma chains, while C4a is released in the plasma (By similarity). -
Subunit
In absence of complement activation, circulates in blood as a disulfide-linked trimer of an alpha, beta and gamma chain
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SwissProt ID
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Synonyms
CO4, CPAMD3, C4B_2, C4B, Complement C4-B, Basic complement C4, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3
Documentation
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