CAMKK2 Antibody (YA7713)

Cat. No.: HY-P88028: Data Sheet User Guide for Antibodies
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CAMKK2 Antibody (YA7713) is a Mouse-derived and non-conjugated IgG1, Kappa monoclonal antibody, targeting to CAMKK2.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation
References

Description

CAMKK2 Antibody (YA7713) is a Mouse-derived and non-conjugated IgG1, Kappa monoclonal antibody, targeting to CAMKK2.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 55 kDa;

Species Reactivity

Human, Mouse

SwissProt ID

Q96RR4

Immunogen

Recombinant human CAMKK2.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-2000

Sensitivity	Endogenous	Purity	affinity purified by Protein G
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG1,k

Appearance

Liquid

Formulation

Supplied in 10mM TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching

Subcellular Localization：Nucleus,Cytoplasm,Cell projection, neuron projection

Expression：
Tissue_Specificity: Ubiquitously expressed with higher levels in the brain. Intermediate levels are detected in spleen, prostate, thyroid and leukocytes. The lowest level is in lung
Induction: Up-regulated by PKA pathway

Isoforms & Post-Translational Modification：Q96RR4 has 7 isomers: Q96RR4-1: 64746 Da (predicted); Q96RR4-2: 58899 Da (predicted); Q96RR4-3: 59602 Da (predicted); Q96RR4-4: 59971 Da (predicted); Q96RR4-5: 54827 Da (predicted); Q96RR4-6: 54124 Da (predicted); Q96RR4-7: 61386 Da (predicted).
Autophosphorylated and phosphorylated by PKA

Subunit：Interacts with calmodulin

Documentation

User Guide for Antibodies (1077 KB)

References

[1]. /biology-dictionary/baf3-cell.html [Content Brief]