CAMKK2 Antibody (YA7713)
(Synonyms: CAMKKB, KIAA0787, CAMKK2, Calcium/calmodulin-dependent protein kinase kinase 2, CaM-KK 2, CaM-kinase kinase 2, CaMKK 2, Calcium/calmodulin-dependent protein kinase kinase beta, CaM-KK beta, CaM-kinase kinase beta, CaMKK beta)CAMKK2 Antibody (YA7713) is a Mouse-derived and non-conjugated IgG1, Kappa monoclonal antibody, targeting to CAMKK2.
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Host:
Mouse
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human, Mouse
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Formulation:
Supplied in 10mM TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:500-2000 |
Product Details
CAMKK2 Antibody (YA7713) is a Mouse-derived and non-conjugated IgG1, Kappa monoclonal antibody, targeting to CAMKK2.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse
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Calculated Molecular Weight Predicted band size: 55 kDa;
Recombinant human CAMKK2.
Endogenous
affinity purified by Protein G
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in 10mM TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CAMKK2 is a Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals. Seems to be involved in hippocampal activation of CREB1. May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching
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Subcellular Localization
Nucleus,Cytoplasm,Cell projection, neuron projection
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Expression
Tissue_Specificity: Ubiquitously expressed with higher levels in the brain. Intermediate levels are detected in spleen, prostate, thyroid and leukocytes. The lowest level is in lung
Induction: Up-regulated by PKA pathway -
Isoforms & Post-Translational Modification
Q96RR4 has 7 isomers: Q96RR4-1: 64746 Da (predicted); Q96RR4-2: 58899 Da (predicted); Q96RR4-3: 59602 Da (predicted); Q96RR4-4: 59971 Da (predicted); Q96RR4-5: 54827 Da (predicted); Q96RR4-6: 54124 Da (predicted); Q96RR4-7: 61386 Da (predicted).
Autophosphorylated and phosphorylated by PKA -
Subunit
Interacts with calmodulin
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SwissProt ID
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Synonyms
CAMKKB, KIAA0787, CAMKK2, Calcium/calmodulin-dependent protein kinase kinase 2, CaM-KK 2, CaM-kinase kinase 2, CaMKK 2, Calcium/calmodulin-dependent protein kinase kinase beta, CaM-KK beta, CaM-kinase kinase beta, CaMKK beta
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