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Cat. No.: HY-P88030

Caspase-5 p20 Antibody (YA7715)

Caspase-5 p20 Antibody (YA7715) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Caspase-5 p20.

For research use only. We do not sell to patients.

Formulation:
Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications

Application	WB WB: Western Blot
Dilution Ratio	1:500-2000

Description

Caspase-5 p20 Antibody (YA7715) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Caspase-5 p20.

Host Rabbit
Clonality Recombinant
Species Reactivity
Human
Observed Molecular Weight

Observed band size: 47 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 50 kDa

Immunogen

A synthesized peptide derived from human Caspase 5

Sensitivity

Endogenous

Purification

affinity purified by Protein A

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Appearance

Liquid
Formulation

Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Function

Caspase-5 p20 is a Thiol protease that acts as a mediator of programmed cell death. Initiates pyroptosis, a programmed lytic cell death pathway through cleavage of Gasdermin-D (GSDMD): cleavage releases the N-terminal gasdermin moiety (Gasdermin-D, N-terminal) that binds to membranes and forms pores, triggering pyroptosis. Also mediates cleavage and maturation of IL18. Cleavage of GSDMD and IL18 is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP4. During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation^[1]^[2]^[3].
Expression

Tissue_Specificity: Expressed in barely detectable amounts in most tissues except brain, highest levels being found in lung, liver and skeletal muscle
Induction: Up-regulated by bacterial lipopolysaccharides (LPS)
Isoforms & Post-Translational Modification

P51878 has 6 isomers: P51878-1: 49736 Da (predicted); P51878-2: 43261 Da (predicted); P51878-3: 33304 Da (predicted); P51878-4: 12694 Da (predicted); P51878-5: 51177 Da (predicted); P51878-6: 41851 Da (predicted).
The two subunits are derived from the precursor sequence by an autocatalytic mechanism
Subunit

Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunits (By similarity)
SwissProt ID

P51878