CCDC93 Antibody (YA8685)
(Synonyms: FLJ10996; FLJ25197; MGC13033)CCDC93 Antibody (YA8685) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CCDC93.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P
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Reactivity :
Human, Dog, Monkey, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:150-500 |
Product Details
CCDC93 Antibody (YA8685) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CCDC93.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Dog, Monkey, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 73 kDa
Human recombinant protein fragment corresponding to amino acids 293-631 of human CCDC93 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CCDC93 component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of composed of the CCC subcomplex and the retriever subcomplex. Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels. The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes and is dependent on its interaction with WASHC2C |(Microbial infection) The CCC complex, in collaboration with the heterotrimeric retriever complex, mediates the exit of human papillomavirus to the cell surface[1][2][3][4].
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Subcellular Localization
Early endosome
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Isoforms & Post-Translational Modification
Q567U6: 631 amino acids, molecular weight 73198 Da.
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Subunit
Component of the commander complex consisting of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:38459129, PubMed:25355947, PubMed:28892079)
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SwissProt ID
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Synonyms
FLJ10996; FLJ25197; MGC13033
Documentation
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