CD276 Antibody (YA1279)
(Synonyms: CD276; B7H3; PSEC0249; CD276 antigen; 4Ig-B7-H3; B7 homolog 3; B7-H3; Costimulatory molecule; CD276)CD276 Antibody (YA1279) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD276.
-
Host:
Rabbit
-
Isotype:
IgG
-
Application:
IHC-P
-
Reactivity :
Human
-
Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.200.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
|
|---|---|
| Dilution Ratio | 1:100-1:200 |
Product Details
CD276 Antibody (YA1279) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD276.
-
Host Rabbit
-
Clonality Recombinant, Monoclonal
-
Species ReactivityHuman
-
Observed Molecular WeightObserved band size: 100 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
-
Calculated Molecular Weight Predicted band size: 57 kDa
A synthesized peptide derived from human CD276
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
-
Appearance
Liquid
-
Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.200.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
CD276 may participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling
-
Subcellular Localization
Membrane; Single-pass type I membrane protein
-
Expression
Tissue_specificity:It is ubiquitous but undetectable in peripheral blood lymphocytes or granulocytes. It is weakly expressed in resting monocytes. It is expressed in monocyte-derived dendritic cells. It is expressed in sinus epithelial cells. It is expressed in extravillous trophoblast cells and Hofbauer cells of the placenta in early pregnancy and at term.
Induction:By bacterial lipopolysaccharides (LPS) in monocytes and by ionomycin in T and B-lymphocytes. Up-regulated in cells mediating rejection of human transplants -
Isoforms & Post-Translational Modification
Q5ZPR3 has 4 isomers: Q5ZPR3-1: 57235 Da (predicted); Q5ZPR3-2: 33791 Da (predicted); Q5ZPR3-3: 52761 Da (predicted); Q5ZPR3-4: 57165 Da (predicted).
-
Subunit
Interacts with TREML2 and this interaction enhances T-cell activation
-
SwissProt ID
-
Synonyms
CD276; B7H3; PSEC0249; CD276 antigen; 4Ig-B7-H3; B7 homolog 3; B7-H3; Costimulatory molecule; CD276
-
Research Field
Immunology
Documentation
Powered by Bioz
