CD74 Antibody (YA4699)
(Synonyms: HLA class II histocompatibility antigen gamma chain; HLA-DR antigens-associated invariant chain; Ia antigen-associated invariant chain; Ii; p33; CD antigen CD74; CD74 nanobody; )CD74 Antibody (YA4699) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD74.
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Host:
Mouse
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Application:
ELISA, FC
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Reactivity :
Human
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Formulation:
Supplied in Phosphate-buffered solution.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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FC
FC: Flow Cytometry
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|---|---|---|
| Dilution Ratio | 1:5000-100000 | 1-2μg/Test |
Product Details
Product Properties
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Appearance
Solution
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Formulation
Supplied in Phosphate-buffered solution.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CD74 (HLA class II histocompatibility antigen gamma chain; HLA-DR antigens-associated invariant chain) is a type II transmembrane protein. CD74 is involved in the formation and transport of MHC class II peptide complexes for the generation of CD4+ T cell responses. Cell surface CD74 serves as a receptor for the cytokine, macrophage migration inhibitory factor (MIF) on many cell types. In immune cells, MIF binding to CD74 induces a signaling cascade that results in regulation of cell proliferation and survival. CD74 has been associated with tumor progression and metastasis. CD74 expression has been suggested to serve as a prognostic factor in many cancers, with higher relative expression behaving as a marker of tumor progression[1].
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Subcellular Localization
Cell membrane; Single-pass type II membrane protein; Endoplasmic reticulum membrane; Golgi apparatus, trans-Golgi network; Endosome; Lysosome; Secreted; Late endosome; Lysosome
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Expression
Tissue_specificity:Protein levels are detectable in urine; it accounts for 10% of total CD74 expression in B cells and 70% of total CD74 expression in other B cells. -
Isoforms & Post-Translational Modification
P04233 has 5 isomers: P04233-1: 33516 Da (predicted); P04233-2: 26399 Da (predicted); P04233-3: 18328 Da (predicted); P04233-4: 31492 Da (predicted); P04233-5: 24375 Da (predicted).
O-glycosylated with core 1 or possibly core 8 glycans (PubMed:22171320, PubMed:23234360). Contains chondroitin sulfate (PubMed:25326458) -
Subunit
Homotrimer. In the endoplasmic reticulum (ER) it forms a heterononameric MHC II-Ii complex: 3 MHC class II molecules (heterodimers of an alpha and a beta subunit) bind to the CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system, the CD74 component undergoes sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide) attached to the MHC class II molecule (alpha-beta-CLIP complex). This processed complex interacts with HLA_DM and HLA_DO heterodimers in order to release CLIP and facilitate the binding of antigenic peptides to the MHC class II molecules. Interacts with CD44; this complex is essential for the MIF-induced signaling cascade that results in B cell survival
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SwissProt ID
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Synonyms
HLA class II histocompatibility antigen gamma chain; HLA-DR antigens-associated invariant chain; Ia antigen-associated invariant chain; Ii; p33; CD antigen CD74; CD74 nanobody;
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