CD85G Antibody (YA4112)
(Synonyms: LILRA4; ILT7)CD85G Antibody (YA4112) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD85G.
-
Host:
Mouse
-
Isotype:
IgG1
-
Application:
WB, ICC/IF, FC, ELISA
-
Reactivity :
Human
-
Formulation:
Supplied in PBS with 0.05% sodium azide
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
|
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
|
|---|---|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:200-1:1000 | 1:200-1:400 | 1:10000 |
Product Details
CD85G Antibody (YA4112) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD85G.
-
Host Mouse
-
Clonality Monoclonal
-
Species ReactivityHuman
-
Observed Molecular WeightObserved band size: 55 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
-
Calculated Molecular Weight Predicted band size: 55.2 kDa
Purified recombinant fragment of human CD85G (AA: extra 24-178) expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
IgG1
Product Properties
-
Appearance
Liquid
-
Formulation
Supplied in PBS with 0.05% sodium azide
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
선적
Shipping with blue ice.
Background
-
Function
CD85G functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G. Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as a negative regulator of TLR7 and TLR9 signaling cascades. Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells. Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+). Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells[1][2][3][4].
-
Subcellular Localization
Cell membrane; Single-pass type I membrane protein
-
Expression
Tissue_specificity:Detected on plasmacytoid dendritic cells (at protein level) . Detected on plasmacytoid dendritic cells, but not on monocytes or B cells -
Isoforms & Post-Translational Modification
P59901 has 2 isomers: P59901-1: 55181 Da (predicted); P59901-2: 47806 Da (predicted).
-
Subunit
Interacts with FCER1G; this stabilizes the expression of both proteins at the cell membrane (PubMed:16735691). Interacts with BST2
-
SwissProt ID
-
Synonyms
LILRA4; ILT7
각종 서류
Powered by Bioz
