CDK2AP1 Antibody
(Synonyms: CDKAP1, DOC1, CDK2AP1, Cyclin-dependent kinase 2-associated protein 1, CDK2-associated protein 1, Deleted in oral cancer 1, Putative oral cancer suppressor, DOC-1)CDK2AP1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to CDK2AP1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 |
Product Details
CDK2AP1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to CDK2AP1.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 12 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 12 kDa
Synthetic peptide corresponding to the center region of human CDK2AP1.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CDK2AP1 is an Inhibitor of cyclin-dependent kinase CDK2 (By similarity). Also acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin[1][2][3].
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Subcellular Localization
Nucleus; Chromosome
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Isoforms & Post-Translational Modification
CDK2AP1 has 2 isoforms, O14519-1: amino acid length is 115, molecular weight is 12365 Da (predicted); O14519-2: amino acid length is 87, molecular weight is 9601 Da (predicted).Phosphorylated in vitro by IKBKE at Ser-46
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Subunit
Homodimer.
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SwissProt ID
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Synonyms
CDKAP1, DOC1, CDK2AP1, Cyclin-dependent kinase 2-associated protein 1, CDK2-associated protein 1, Deleted in oral cancer 1, Putative oral cancer suppressor, DOC-1
Documentation
[1]. Le Guezennec X, et al. MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties. Mol Cell Biol. 2006 Feb;26(3):843-51. [Content Brief]
[2]. Spruijt CG, et al. CDK2AP1/DOC-1 is a bona fide subunit of the Mi-2/NuRD complex. Mol Biosyst. 2010 Sep;6(9):1700-6. [Content Brief]
[3]. Hoffmeister H, et al. CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality. Nucleic Acids Res. 2017 Oct 13;45(18):10534-10554. [Content Brief]
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