Cytokeratin 15 Antibody (YA6385)
(Synonyms: K1C15_HUMAN; Cytokeratin-15; CK 15; CK-15; CK15; Cytokeratin15; K15; K1CO; Keratin 15; Keratin 15 basic; Keratin 15 beta; Keratin complex 1 acidic gene 15; Keratin type I cytoskeletal 15; Keratin15; KRT 15; KRTB; KRTL15; keratin-15, basic; Type I cytoskeletal 15.)Cytokeratin 15 Antibody (YA6385) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cytokeratin 15.
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Host:
Rabbit
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Isotype:
IgG
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Application:
IHC-P, IHC-F, IF-Tissue
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Reactivity :
Human, Rat, Mouse
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Formulation:
Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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IHC-F
IHC-F: Immunohistochemistry-Frozen
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:100-500 | 1:100-500 | 1:100-500 |
Product Details
Cytokeratin 15 Antibody (YA6385) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cytokeratin 15.
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Host Rabbit
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Clonality Monoclonal
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Species ReactivityHuman, Rat, Mouse
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Calculated Molecular Weight Predicted band size: 49 kDa
Recombinant human Cytokeratin 15 protein, around C-terminal 100aa
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Cytokeratin 15 (CK15), also known as keratin-15 (KRT15), has been described as a stem cell marker based on its expression in human hair follicles and other organs. In animal models, CK15 has been shown to be a marker expressed in self-renewing, regenerative progenitor stem cells. In the breast, CK15 expression was reported in resting undifferentiated ductal luminal cells, with evidence linking CK15 expression with immature and basal-like properties. As for human cancers, CK15 expression is associated with aggressive tumour features and poor clinical outcomes in endometrial and oesophageal cancers[1].
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Expression
Tissue_Specificity: Expressed in a discontinuous manner in the basal cell layer of adult skin epidermis, but continuously in the basal layer of fetal skin epidermis and nail. Also expressed in the outer root sheath above the hair bulb in hair follicle (at protein level). Expressed homogeneously in all cell layers of the esophagus and exocervix, but detected in the basal cell layer only of oral mucosa, skin and in the basal plus the next two layers of the suprabasal epithelium of the palate -
Isoforms & Post-Translational Modification
Cytokeratin 15 has 2 isomers: P19012-1: 49,212 Da (predicted); P19012-2: 28,602 Da (predicted).
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Subunit
Heterotetramer of two type I and two type II keratins (By similarity). Forms a heterodimer with KRT14. Interacts with PLEC isoform 1C, when in a heterodimer with KRT14. Interacts with NOD2
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SwissProt ID
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Synonyms
K1C15_HUMAN; Cytokeratin-15; CK 15; CK-15; CK15; Cytokeratin15; K15; K1CO; Keratin 15; Keratin 15 basic; Keratin 15 beta; Keratin complex 1 acidic gene 15; Keratin type I cytoskeletal 15; Keratin15; KRT 15; KRTB; KRTL15; keratin-15, basic; Type I cytoskeletal 15.
Documentation
References
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