2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies
  5. DEF6 Antibody (YA8049)(PBS only)

DEF6 Antibody (YA8049)(PBS only)

Cat. No.: HY-P88365A
User Guide for Antibodies Technical Support

DEF6 Antibody (YA8049) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DEF6.

For research use only. We do not sell to patients.

Size Stock
50 μL   Get quote  
100 μL   Get quote  

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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

Description

DEF6 Antibody (YA8049) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DEF6.
Host

Mouse
Molecular Weight

Predicted band size: 73.7 kDa
Species Reactivity
Human, Mouse, Rat
SwissProt ID
Immunogen

Full length human recombinant protein of human DEF6 produced in HEK293T cell.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-2000
IHC-P
IHC-P: Immunohistochemistry-Paraffin
1:100-500
Purity Affinity purified Conjugation Non-conjugated
Isotype IgG1  
Appearance

Liquid
Formulation

Supplied in PBS, pH 7.4.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42 (PubMed:12651066, PubMed:15023524). Can regulate cell morphology in cooperation with activated RAC1 (By similarity). Involved in immune homeostasis by ensuring proper trafficking and availability of T-cell regulator CTLA-4 at T-cell surface (PubMed:31308374). Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling (By similarity)
Subcellular Localization：Cytoplasm,Cell membrane,Nucleus,Cytoplasm, cytoskeleton,Cytoplasm, perinuclear region,Cell projection, filopodium
Expression：
Tissue_Specificity: Broadly expressed in the immune system. Highly expressed in T cells (PubMed:31308374)
Isoforms & Post-Translational Modification：Q9H4E7: 631 amino acids, molecular weight 73910 Da.
Subunit：Interacts with ZAP70 (By similarity)
Synonyms
IBP; SLAT; SWAP70L
Documentation
User Guide for Antibodies (1077 KB)

DEF6 Antibody (YA8049)(PBS only) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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DEF6 Antibody (YA8049)(PBS only)
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