DEF6 Antibody (YA8049)
(Synonyms: IBP; SLAT; SWAP70L)DEF6 Antibody (YA8049) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DEF6.
-
Host:
Mouse
-
Isotype:
IgG1
-
Application:
WB, IHC-P
-
Reactivity :
Human, Mouse, Rat
-
Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
IHC-P
IHC-P: Immunohistochemistry-Paraffin
|
|---|---|---|
| Dilution Ratio | 1:500-2000 | 1:100-500 |
Product Details
DEF6 Antibody (YA8049) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DEF6.
-
Host Mouse
-
Clonality Monoclonal
-
Species ReactivityHuman, Mouse, Rat
-
Calculated Molecular Weight Predicted band size: 73.7 kDa
Full length human recombinant protein of human DEF6 produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
-
Appearance
Liquid
-
Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
DEF6 is a Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Involved in immune homeostasis by ensuring proper trafficking and availability of T-cell regulator CTLA-4 at T-cell surface. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling[1][2][3].
-
Subcellular Localization
Cytoplasm,Cell membrane,Nucleus,Cytoplasm, cytoskeleton,Cytoplasm, perinuclear region,Cell projection, filopodium
-
Expression
Tissue_Specificity: Broadly expressed in the immune system. Highly expressed in T cells (PubMed:31308374) -
Isoforms & Post-Translational Modification
Q9H4E7: 631 amino acids, molecular weight 73910 Da.
-
Subunit
Interacts with ZAP70 (By similarity)
-
SwissProt ID
-
Synonyms
IBP; SLAT; SWAP70L
Documentation
Powered by Bioz
