DPP8 Antibody (YA7861)

Dipeptidyl peptidase 8 (DPP-8) is an intracellular serine protease of the S9B family that cleaves N-terminal dipeptides from substrates containing a penultimate proline residue and is broadly expressed in mammalian tissues and immune cells^[1]. DPP-8 participates in multiple biological functions, including immune regulation, cell proliferation, apoptosis, energy metabolism, and inflammatory responses, indicating a central role in maintaining cellular homeostasis^[1][2]. Mechanistically, accumulating evidence places DPP-8 within inflammasome-associated pathways, where DPP8/9 activity suppresses inappropriate activation of innate immune signaling upstream of NLRP1-related responses^[3][4]. In disease-relevant experimental systems, pharmacological inhibition of DPP8/9 activates inflammasome signaling and pyroptotic cell death in immune cells, highlighting the importance of DPP-8 in regulating inflammatory cell fate decisions^[3][4]. Compared with the closely related isoform DPP-9, DPP-8 shares high structural and enzymatic similarity but appears to have partially distinct biological associations; available evidence suggests DPP-8 may be more closely linked to gut inflammation, whereas DPP-9 has stronger connections with antigen presentation and intracellular signaling pathways^[2]. Therefore, distinguishing DPP-8 from DPP-9 remains important when interpreting experimental outcomes and designing mechanistic studies^[2]. For experimental applications, selective DPP8/9 inhibitors have become valuable research tools for investigating inflammasome regulation, pyroptosis, immune-cell activation, and inflammatory disease mechanisms^[1][3][4].