DRD2 Antibody

Cat. No.: HY-P81092: Data Sheet COA
SDS
User Guide for Antibodies
FAQs
Technical Support

DRD2 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to DRD2.

For research use only. We do not sell to patients.

Size	Stock	Quantity
Free Sample	Apply now
10 μL	In-stock	Estimated Time of Arrival: December 31
50 μL	In-stock	Estimated Time of Arrival: December 31
100 μL	In-stock	Estimated Time of Arrival: December 31
250 μL	Get quote

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DRD2 Antibody Featured Recommendations:

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
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Background
Documentation

Description

DRD2 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to DRD2.

Host

Rabbit

Clonality

Polyclonal

Molecular Weight

Predicted band size: 51 kDa;

Observed band size: 50 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Mouse, Rat Predicted Reactivity: Human

Note: The predicted reactivity is for reference only and should not be considered a guarantee of product performance.

SwissProt ID

P14416

Gene ID

1813 [NCBI]

Immunogen

KLH conjugated synthetic peptide derived from human DRD2: 201-300/443

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-2000

Sensitivity	Endogenous	Purity	affinity purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Verification Image

Western blot analysis of extracts from SH-SY5Y (lane 2(20μg), U-87 (lane 3(20μg),THP-1 (lane 4(20μg) using DRD2 Antibody. Proteins were transferred to a PVDF membrane and blocked with 5% BSA in TBST for 2 hour at room temperature. The primary antibody and Loading control antibody (Beta Actin, HY-P80438, 1/3000) was used in 5% BSA in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (HY-P8004/HY-P8001, 1/10,000) was used for 1 hour at room temperature.

Background

Function：Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (PubMed:21645528). Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5 (By similarity)

Subcellular Localization：Cell membrane; Multi-pass membrane protein; Golgi apparatus membrane; Multi-pass membrane protein

Expression：
Tissue_specificity:Expressed in the anterior pituitary gland; Expressed in the anterior pituitary gland

Isoforms & Post-Translational Modification：P14416 has 3 isomers: P14416-1: 50619 Da (predicted); P14416-2: 47347 Da (predicted); P14416-3: 50847 Da (predicted).
Palmitoylated. Palmitoylation which is required for proper localization to the plasma membrane and stability of the receptor could be carried on by ZDHHC4, ZDHHC3 and ZDHHC8

Subunit：Forms homo- and heterooligomers with DRD4 (PubMed:21184734). The interaction with DRD4 may modulate agonist-induced downstream signaling (PubMed:21184734). Interacts with CADPS and CADPS2 (PubMed:15857609). Interacts with GPRASP1, PPP1R9B and CLIC6 (By similarity). Interacts with ARRB2 (By similarity). Interacts with HTR2A (PubMed:21645528). Interacts with GNAI2 isoform sGi2, the interaction allows the creation of an intracellular pool of DRD2 that can be released to cell surface upon agonist stimulation (PubMed:17550964). Interacts with DRD1 (By similarity). Interacts with KCNA2 (By similarity)

RRID

AB_3103203

Database

Entrez Gene: 1813 Human ; 13489 Mouse ; 24318 Rat

SwissProt: P14416 Human ; P61168 Mouse ; P61169 Rat

OMIM: 103780 Human

Synonyms

DRD2_HUMAN; D(2) dopamine receptor; Dopamine D2 receptor; dopamine receptor D2; D2R; D2DR;

Documentation

Select Batch:

Data Sheet (231 KB) SDS (251 KB)

COA (205 KB)

User Guide for Antibodies (1077 KB)

DRD2 Antibody Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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DRD2 Antibody

DRD2 Antibody Featured Recommendations:

Product Detail

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Background

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DRD2 Antibody Related Classifications

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