DUSP6 Antibody (YA2280)(PBS only)

Cat. No.: HY-P82535A: Data Sheet User Guide for Antibodies
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DUSP6 Antibody (YA2280) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DUSP6.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

DUSP6 Antibody (YA2280) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DUSP6.

Host

Rabbit

Molecular Weight

Predicted band size: 42 kDa;

Observed band size: 42 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q16828

Gene ID

1848 [NCBI]

Immunogen

A synthesized peptide derived from human DUSP6

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:50-1:100
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:50-1:200
IP IP: Immunoprecipitation	1:50
FC FC: Flow Cytometry	1:50-1:100

Purity	Affinity Chromatography	Conjugation	Non-conjugated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Dual specificity protein phosphatase, which mediates dephosphorylation and inactivation of MAP kinases (PubMed:8670865). Has a specificity for the ERK family (PubMed:8670865). Plays an important role in alleviating chronic postoperative pain (By similarity). Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity). Promotes cell differentiation by regulating MAPK1/MAPK3 activity and regulating the expression of AP1 transcription factors (PubMed:29043977)

Subcellular Localization：Cytoplasm

Expression：
Tissue_specificity:Expressed in keratinocytes (at protein level)

Isoforms & Post-Translational Modification：Q16828 has 2 isomers: Q16828-1: 42320 Da (predicted); Q16828-2: 26468 Da (predicted).
Ubiquitinated by the SCF(FBXO31) complex, leading to its proteasomal degradation

Subunit：Interacts with MAPK1/ERK2

Research Field

Neuroscience

Synonyms

HH19; MKP3; PYST1; DUSP6; DUSP6a; Dual specificity phosphatase 6

Documentation

User Guide for Antibodies (1077 KB)