Dysbindin 1 Antibody
(Synonyms: BLOC1S8, My031, DTNBP1, Dysbindin, Biogenesis of lysosome-related organelles complex 1 subunit 8, Dysbindin-1, Dystrobrevin-binding protein 1, Hermansky-Pudlak syndrome 7 protein, BLOC-1 subunit 8, HPS7 protein)Dysbindin 1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Dysbindin 1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 |
Product Details
Dysbindin 1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Dysbindin 1.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 48 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 30; 34; 39 kDa
Purified recombinant protein of human Dysbindin 1
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Dysbindin 1 is a Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic release. Regulates the expression of SYN1 through binding to its promoter. Modulates prefrontal cortical activity via the dopamine/D2 pathway
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Subcellular Localization
Cytoplasm; Cytoplasmic vesicle membrane; Endosome membrane; Melanosome membrane; Postsynaptic density; Endoplasmic reticulum; Nucleus
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Expression
Tissue_Specificity: Detected in brain, in neurons and in neuropil. Isoform 1 is expressed in the cerebral cortex, and hippocampal frontal (HF). Specific expression in the posterior half of the superior temporal gyrus (pSTG). Higher expression of isoform 2 and 3 in the HF than in the pSTG while isoform 1 shows no difference in expression in these areas. In the HF, detected in dentate gyrus (DG) and in pyramidal cells of hippocampus CA2 and CA3 (at protein level). Expressed in all principal neuronal populations of the HF, namely pyramidal neurons in the subiculum and CA1-3, granule cells in the dense cell layer of the DG (DGg), and polymorph cells in the hilus of the DG (DGh). Maximal levels in CA2, CA3, and DGh. Isoform 2 not expressed in the cerebral cortex. -
Isoforms & Post-Translational Modification
Dysbindin 1 has 3 isoforms, Q96EV8-1: amino acid length is 351, molecular weight is 39493 Da (predicted); Q96EV8-2: amino acid length is 303, molecular weight is 34831 Da (predicted); Q96EV8-3: amino acid length is 270, molecular weight is 30387 Da (predicted).可被 TRIM32 泛素化，该泛素化会导致 DTNBP1 降解Dysbindin 1 存在 3 个异构体，Q96EV8-1：氨基酸个数为 351 个，分子量为 39493 Da (预测)；Q96EV8-2：氨基酸个数为 303 个，分子量为 34831 Da (预测)；Q96EV8-3：氨基酸个数为 270 个，分子量为 30387 Da (预测)。Ubiquitinated by TRIM32. Ubiquitination leads to DTNBP1 degradation
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Subunit
Interacts (via its coiled coil domain) with KXD1.
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SwissProt ID
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Synonyms
BLOC1S8, My031, DTNBP1, Dysbindin, Biogenesis of lysosome-related organelles complex 1 subunit 8, Dysbindin-1, Dystrobrevin-binding protein 1, Hermansky-Pudlak syndrome 7 protein, BLOC-1 subunit 8, HPS7 protein
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