EDA Antibody
(Synonyms: ED1, EDA2, EDA, Ectodysplasin-A, Ectodermal dysplasia protein, EDA protein)EDA Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to EDA.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 |
Product Details
EDA Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to EDA.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse
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Observed Molecular WeightObserved band size: 41 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 41 kDa
Synthetic peptide corresponding to the center region of human EDA.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
EDA is a Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R. May also play a role in cell adhesion (By similarity)[1][2][3][4].
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Subcellular Localization
Cell membrane
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Expression
Tissue_Specificity: Not abundant; expressed in specific cell types of ectodermal (but not mesodermal) origin of keratinocytes, hair follicles, sweat glands. Also in adult heart, liver, muscle, pancreas, prostate, fetal liver, uterus, small intestine and umbilical cord. -
Isoforms & Post-Translational Modification
EDA has 8 isoforms, Q92838-1: amino acid length is 391, molecular weight is 41294 Da (predicted); Q92838-2: amino acid length is 135, molecular weight is 14048 Da (predicted); Q92838-3: amino acid length is 389, molecular weight is 41065 Da (predicted); Q92838-5: amino acid length is 147, molecular weight is 15097 Da (predicted); Q92838-6: amino acid length is 142, molecular weight is 14798 Da (predicted); Q92838-7: amino acid length is 148, molecular weight is 15582 Da (predicted); Q92838-8: amino acid length is 147, molecular weight is 15443 Da (predicted); Q92838-9: amino acid length is 386, molecular weight is 40750 Da (predicted).可发生 N-糖基化EDA 存在 8 个异构体，Q92838-1：氨基酸个数为 391 个，分子量为 41294 Da (预测)；Q92838-2：氨基酸个数为 135 个，分子量为 14048 Da (预测)；Q92838-3：氨基酸个数为 389 个，分子量为 41065 Da (预测)；Q92838-5：氨基酸个数为 147 个，分子量为 15097 Da (预测)；Q92838-6：氨基酸个数为 142 个，分子量为 14798 Da (预测)；Q92838-7：氨基酸个数为 148 个，分子量为 15582 Da (预测)；Q92838-8：氨基酸个数为 147 个，分子量为 15443 Da (预测)；Q92838-9：氨基酸个数为 386 个，分子量为 40750 Da (预测)。N-glycosylated
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Subunit
Homotrimer.
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SwissProt ID
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Synonyms
ED1, EDA2, EDA, Ectodysplasin-A, Ectodermal dysplasia protein, EDA protein
Documentation
[1]. Yan M, et al. Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors. Science. 2000 Oct 20;290(5491):523-7. [Content Brief]
[2]. Shen W, et al. RETRACTED: Functional Study of Ectodysplasin-A Mutations Causing Non-Syndromic Tooth Agenesis. PLoS One. 2016;11(5):e0154884. [Content Brief]
[3]. Yu K, et al. Two novel ectodysplasin A gene mutations and prenatal diagnosis of X-linked hypohidrotic ectodermal dysplasia. Mol Genet Genomic Med. 2021 Nov;9(11):e1824. [Content Brief]
[4]. Kere J, et al. X-linked anhidrotic (hypohidrotic) ectodermal dysplasia is caused by mutation in a novel transmembrane protein. Nat Genet. 1996 Aug;13(4):409-16. [Content Brief]
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