EHHADH Antibody (YA8059)(PBS only)
(Synonyms: ECHD; FRTS3; L-PBE; LBFP; LBP; PBFE)EHHADH Antibody (YA8059) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to EHHADH.
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Host:
Mouse
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:1000-4000 | 1:150-500 |
Product Details
EHHADH Antibody (YA8059) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to EHHADH.
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Host Mouse
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 79.3 kDa
Human recombinant protein fragment corresponding to amino acids 496-723 of human EHHADH produced in E.coli.
Affinity purified
Non-conjugated
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
EHHADH is a Peroxisomal trifunctional enzyme possessing 2-enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase, and delta 3, delta 2-enoyl-CoA isomerase activities. Catalyzes two of the four reactions of the long chain fatty acids peroxisomal beta-oxidation pathway. Can also use branched-chain fatty acids such as 2-methyl-2E-butenoyl-CoA as a substrate, which is hydrated into (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA. Optimal isomerase for 2,5 double bonds into 3,5 form isomerization in a range of enoyl-CoA species (Probable). Also able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. With HSD17B4, catalyzes the hydration of trans-2-enoyl-CoA and the dehydrogenation of 3-hydroxyacyl-CoA, but with opposite chiral specificity. Regulates the amount of medium-chain dicarboxylic fatty acids which are essential regulators of all fatty acid oxidation pathways. Also involved in the degradation of long-chain dicarboxylic acids through peroxisomal beta-oxidation[1].
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Subcellular Localization
Peroxisome
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Expression
Tissue_Specificity: Liver and kidney. Strongly expressed in the terminal segments of the proximal tubule. Lower amounts seen in the brain -
Isoforms & Post-Translational Modification
Q08426 has two isomers: Q08426-1: 79495 Da (predicted); Q08426-2: 69154 Da (predicted).
Acetylated, leading to enhanced enzyme activity -
Subunit
Monomer
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SwissProt ID
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Synonyms
ECHD; FRTS3; L-PBE; LBFP; LBP; PBFE
Documentation
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