EI2BG Antibody (YA4519)
(Synonyms: EIF2B3; EIF-2B; EIF2Bgamma)EI2BG Antibody (YA4519) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to EI2BG.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, IHC-P, ICC/IF, FC
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Reactivity :
Human
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Formulation:
Supplied in PBS with 0.05% sodium azide
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:200-1:1000 | 1:50-1:200 | 1:200-1:400 |
Product Details
EI2BG Antibody (YA4519) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to EI2BG.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 48 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 50 kDa
Purified recombinant fragment of human EI2BG aa 110-452(KLH ).
affinity purified.
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS with 0.05% sodium azide
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
EI2BG acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed[1][2][3].
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Subcellular Localization
Cytoplasm, cytosol
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Isoforms & Post-Translational Modification
Q9NR50 has 3 isomers: Q9NR50-1: 50240 Da (predicted); Q9NR50-2: 46145 Da (predicted); Q9NR50-3: 44803 Da (predicted).
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Subunit
Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex (PubMed:25858979, PubMed:27023709, PubMed:31048492). Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides (PubMed:31048492)
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SwissProt ID
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Synonyms
EIF2B3; EIF-2B; EIF2Bgamma
Documentation
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